Adenine

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Condensed phase thermochemistry data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
ALS - Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein
DH - Eugene S. Domalski and Elizabeth D. Hearing

Quantity Value Units Method Reference Comment
Δfsolid23.2 ± 0.31kcal/molCcrKirklin and Domalski, 1983ALS
Δfsolid22.95 ± 0.22kcal/molCcbStiehler and Huffman, 1935Reanalyzed by Cox and Pilcher, 1970, Original value = 21.76 kcal/mol; ALS
Quantity Value Units Method Reference Comment
Δcsolid-664.20 ± 0.30kcal/molCcrKirklin and Domalski, 1983ALS
Δcsolid-663.99 ± 0.21kcal/molCcbStiehler and Huffman, 1935Reanalyzed by Cox and Pilcher, 1970, Original value = -663.74 ± 0.21 kcal/mol; ALS
Quantity Value Units Method Reference Comment
solid,1 bar36.092cal/mol*KN/AStiehler and Huffman, 1935, 2Extrapolation below 90 K, 46.69 J/mol*K.; DH

Constant pressure heat capacity of solid

Cp,solid (cal/mol*K) Temperature (K) Reference Comment
35.13298.Kilday, 1978DH
34.209298.1Stiehler and Huffman, 1935, 2T = 88 to 298 K. Value is unsmoothed experimental datum.; DH

Reaction thermochemistry data

Go To: Top, Condensed phase thermochemistry data, Gas phase ion energetics data, References, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
B - John E. Bartmess
M - Michael M. Meot-Ner (Mautner) and Sharon G. Lias
RCD - Robert C. Dunbar

Note: Please consider using the reaction search for this species. This page allows searching of all reactions involving this species. A general reaction search form is also available. Future versions of this site may rely on reaction search pages in place of the enumerated reaction displays seen below.

Individual Reactions

adeninide anion + Hydrogen cation = Adenine

By formula: C5H4N5- + H+ = C5H5N5

Quantity Value Units Method Reference Comment
Δr335.1 ± 2.2kcal/molG+TSSharma and Lee, 2002gas phase; Acidity at N-9(imidazole N); B
Quantity Value Units Method Reference Comment
Δr328.0 ± 2.0kcal/molIMRBSharma and Lee, 2002gas phase; Acidity at N-9(imidazole N); B
Δr344.3 ± 4.0kcal/molIMRBSharma and Lee, 2002gas phase; Less acidic N-10 site(aniline); B

C5H6N5+ + Adenine = (C5H6N5+ • Adenine)

By formula: C5H6N5+ + C5H5N5 = (C5H6N5+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr30.3kcal/molPHPMSMeot-Ner (Mautner), 1979gas phase; M
Quantity Value Units Method Reference Comment
Δr39.cal/mol*KPHPMSMeot-Ner (Mautner), 1979gas phase; M

Sodium ion (1+) + Adenine = (Sodium ion (1+) • Adenine)

By formula: Na+ + C5H5N5 = (Na+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr33.4 ± 1.0kcal/molCIDTRodgers and Armentrout, 2000RCD
Δr41.1kcal/molCIDCCerda and Wesdemiotis, 1996RCD

Titanium ion (1+) + Adenine = (Titanium ion (1+) • Adenine)

By formula: Ti+ + C5H5N5 = (Ti+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr≤81.1 ± 3.5kcal/molCIDTRodgers and Armentrout, 2002RCD

Vanadium ion (1+) + Adenine = (Vanadium ion (1+) • Adenine)

By formula: V+ + C5H5N5 = (V+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr≤63.4 ± 2.5kcal/molCIDTRodgers and Armentrout, 2002RCD

Zinc ion (1+) + Adenine = (Zinc ion (1+) • Adenine)

By formula: Zn+ + C5H5N5 = (Zn+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr≥57.0 ± 1.3kcal/molCIDTRodgers and Armentrout, 2002RCD

Iron ion (1+) + Adenine = (Iron ion (1+) • Adenine)

By formula: Fe+ + C5H5N5 = (Fe+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr62.0 ± 2.1kcal/molCIDTRodgers and Armentrout, 2002RCD

Chromium ion (1+) + Adenine = (Chromium ion (1+) • Adenine)

By formula: Cr+ + C5H5N5 = (Cr+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr55.1 ± 1.8kcal/molCIDTRodgers and Armentrout, 2002RCD

Manganese ion (1+) + Adenine = (Manganese ion (1+) • Adenine)

By formula: Mn+ + C5H5N5 = (Mn+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr51.6 ± 1.8kcal/molCIDTRodgers and Armentrout, 2002RCD

Nickel ion (1+) + Adenine = (Nickel ion (1+) • Adenine)

By formula: Ni+ + C5H5N5 = (Ni+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr71.1 ± 2.3kcal/molCIDTRodgers and Armentrout, 2002RCD

Cobalt ion (1+) + Adenine = (Cobalt ion (1+) • Adenine)

By formula: Co+ + C5H5N5 = (Co+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr70.0 ± 2.5kcal/molCIDTRodgers and Armentrout, 2002RCD

Copper ion (1+) + Adenine = (Copper ion (1+) • Adenine)

By formula: Cu+ + C5H5N5 = (Cu+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr70.3 ± 2.6kcal/molCIDTRodgers and Armentrout, 2002RCD

Potassium ion (1+) + Adenine = (Potassium ion (1+) • Adenine)

By formula: K+ + C5H5N5 = (K+ • C5H5N5)

Quantity Value Units Method Reference Comment
Δr25.3kcal/molCIDCCerda and Wesdemiotis, 1996RCD

Gas phase ion energetics data

Go To: Top, Condensed phase thermochemistry data, Reaction thermochemistry data, References, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data evaluated as indicated in comments:
HL - Edward P. Hunter and Sharon G. Lias

Data compiled as indicated in comments:
B - John E. Bartmess
LLK - Sharon G. Lias, Rhoda D. Levin, and Sherif A. Kafafi
RDSH - Henry M. Rosenstock, Keith Draxl, Bruce W. Steiner, and John T. Herron

Quantity Value Units Method Reference Comment
Proton affinity (review)225.3kcal/molN/AHunter and Lias, 1998HL
Quantity Value Units Method Reference Comment
Gas basicity218.1kcal/molN/AHunter and Lias, 1998HL

Electron affinity determinations

EA (eV) Reference Comment
0.0120 ± 0.0050Desfrancois, Abdoul-Carime, et al., 1996 Aflatooni, Gallup, et al., 1998: vertical attachment EA = -0.54 eV; B

Ionization energy determinations

IE (eV) Method Reference Comment
8.3 ± 0.1EIVerkin, Sukodub, et al., 1976LLK
8.9 ± 0.1EILifschitz, Bergmann, et al., 1967RDSH
8.48PELin, Yu, et al., 1980Vertical value; LLK
8.48PEPeng, Padva, et al., 1976Vertical value; LLK
8.44 ± 0.03PEHush and Cheung, 1975Vertical value; LLK

De-protonation reactions

adeninide anion + Hydrogen cation = Adenine

By formula: C5H4N5- + H+ = C5H5N5

Quantity Value Units Method Reference Comment
Δr335.1 ± 2.2kcal/molG+TSSharma and Lee, 2002gas phase; Acidity at N-9(imidazole N); B
Quantity Value Units Method Reference Comment
Δr328.0 ± 2.0kcal/molIMRBSharma and Lee, 2002gas phase; Acidity at N-9(imidazole N); B
Δr344.3 ± 4.0kcal/molIMRBSharma and Lee, 2002gas phase; Less acidic N-10 site(aniline); B

References

Go To: Top, Condensed phase thermochemistry data, Reaction thermochemistry data, Gas phase ion energetics data, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Kirklin and Domalski, 1983
Kirklin, D.R.; Domalski, E.S., Enthalpy of combustion of adenine, J. Chem. Thermodyn., 1983, 15, 941-947. [all data]

Stiehler and Huffman, 1935
Stiehler, R.D.; Huffman, H.M., Thermal data. IV. The heats of combustion of adenine, hypoxanthine, guanine, xanthine, uric acid, allantoin and alloxan, J. Am. Chem. Soc., 1935, 57, 1734-1740. [all data]

Cox and Pilcher, 1970
Cox, J.D.; Pilcher, G., Thermochemistry of Organic and Organometallic Compounds, Academic Press, New York, 1970, 1-636. [all data]

Stiehler and Huffman, 1935, 2
Stiehler, R.D.; Huffman, H.M., Thermal data. V. The heat capacities, entropies and free energies of adenine, hypoxanthine, guanine, xanthine, uric acid, allantoin and alloxan, J. Am. Chem. Soc., 1935, 57, 1741-1743. [all data]

Kilday, 1978
Kilday, M.V., Enthalpies of solution of the nucleic acid bases. 1. Adenine in water, J. Res., 1978, NBS 83, 347-369. [all data]

Sharma and Lee, 2002
Sharma, S.; Lee, J.K., Acidity of adenine and adenine derivatives and biological implications. A computational and experimental gas-phase study, J. Org. Chem., 2002, 67, 24, 8360-8365, https://doi.org/10.1021/jo0204303 . [all data]

Meot-Ner (Mautner), 1979
Meot-Ner (Mautner), M., Ion Thermochemistry of Low Volatility Compounds in the Gas Phase. II. Intrinsic Basicities and Hydrogen Bonded Dimers of Nitrogen Heterocyclics and Nucleic Bases, J. Am. Chem. Soc., 1979, 101, 9, 2396, https://doi.org/10.1021/ja00503a027 . [all data]

Rodgers and Armentrout, 2000
Rodgers, M.T.; Armentrout, P.B., Noncovalent Interactions of Nucleic Acid Bases (Uracil, Thymine, and Adenine) with Alkali Metal Ions. Threshold Collision-Induced Dissociation and Theoretical Studies, J. Am. Chem. Soc., 2000, 121, 35, 8548, https://doi.org/10.1021/ja001638d . [all data]

Cerda and Wesdemiotis, 1996
Cerda, B.A.; Wesdemiotis, C., PAs of Peptides, J. Am. Chem. Soc., 1996, 118, 11884. [all data]

Rodgers and Armentrout, 2002
Rodgers, M.T.; Armentrout, P.B., Influence of d orbital occupation on the binding of metal ions to adenine, J. Am. Chem. Soc., 2002, 124, 11, 2678, https://doi.org/10.1021/ja011278+ . [all data]

Hunter and Lias, 1998
Hunter, E.P.; Lias, S.G., Evaluated Gas Phase Basicities and Proton Affinities of Molecules: An Update, J. Phys. Chem. Ref. Data, 1998, 27, 3, 413-656, https://doi.org/10.1063/1.556018 . [all data]

Desfrancois, Abdoul-Carime, et al., 1996
Desfrancois, C.; Abdoul-Carime, H.; Schermann, J.P., Electron Attachment to Isolated Nucleic Acid Bases, J. Chem. Phys., 1996, 104, 19, 7792, https://doi.org/10.1063/1.471484 . [all data]

Aflatooni, Gallup, et al., 1998
Aflatooni, K.; Gallup, G.A.; Burrows, P.D., Electron Attachment Energies of the DNA Bases, J. Phys. Chem., 1998, 102, 31, 6205, https://doi.org/10.1021/jp980865n . [all data]

Verkin, Sukodub, et al., 1976
Verkin, B.I.; Sukodub, L.F.; Yanson, I.K., Ionization potentials of nitrogenous bases of of nucleic acids, Dokl. Akad. Nauk SSSR, 1976, 228, 1452. [all data]

Lifschitz, Bergmann, et al., 1967
Lifschitz, C.; Bergmann, E.D.; Pullman, B., The ionization potentials of biological purines and pyrimidines, Tetrahedron Lett., 1967, 4583. [all data]

Lin, Yu, et al., 1980
Lin, J.; Yu, C.; Peng, S.; Akiyama, I.; Li, K.; Lee, L.K.; LeBreton, P.R., Ultraviolet photoelectron studies of the ground-state electronic structure and gas-phase tautomerism of purine and adenine, J. Am. Chem. Soc., 1980, 102, 4627. [all data]

Peng, Padva, et al., 1976
Peng, S.; Padva, A.; LeBreton, P.R., Ultraviolet photoelectron studies of biological purines: The valence electronic structure of adenine, Proc. Nat. Acad. Sci. U.S.A., 1976, 73, 2966. [all data]

Hush and Cheung, 1975
Hush, N.S.; Cheung, A.S., Ionization potentials and donor properties of nucleic acid bases and related compounds, Chem. Phys. Lett., 1975, 34, 11. [all data]


Notes

Go To: Top, Condensed phase thermochemistry data, Reaction thermochemistry data, Gas phase ion energetics data, References