Niflumic acid

• Formula: C₁₃H₉F₃N₂O₂
• Molecular weight: 282.2180
• IUPAC Standard InChI: InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) Copy

  
• IUPAC Standard InChIKey: JZFPYUNJRRFVQU-UHFFFAOYSA-N Copy
• CAS Registry Number: 4394-00-7
• Chemical structure:
  This structure is also available as a 2d Mol file or as a computed 3d SD file
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• Other names: 3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-; Nicotinic acid, 2-(α,α,α-trifluoro-m-toluidino)-; Actol; Actol, analgesic; Flogovital; Forenol; Landruma; Nifluminic acid; Nifluril; UP 83; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; Acide niflumique; Acido niflumico; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; 2-[3-(Trifluoromethyl)anilino]-3-pyridinecarboxylic acid; Niflamol; 2-[3-(Trifluoromethyl)anilino]nicotinic acid (niflumic acid)
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• Information on this page:
  • Phase change data
  • Mass spectrum (electron ionization)
  • Gas Chromatography
  • References
  • Notes
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos

Enthalpy of sublimation

Enthalpy of fusion

Mass spectrum (electron ionization)

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Additional Data

Gas Chromatography

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Kovats' RI, non-polar column, isothermal

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References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Pinvidic, Gonthier-Vassal, et al., 1989
Pinvidic, J.J.; Gonthier-Vassal, A.; Szwarc, H.; Ceolin, R.; Toffoli, P.; Teulon, J.M.; Guechot, C., Niflumic acid-morniflumate phase diagram: 1. Study of the components, Thermochim. Acta, 1989, 153, 37-45. [all data]

Perlovich, Surov, et al., 2007
Perlovich, German L.; Surov, Artem O.; Bauer-Brandl, Annette, Thermodynamic properties of flufenamic and niflumic acids---Specific and non-specific interactions in solution and in crystal lattices, mechanism of solvation, partitioning and distribution, Journal of Pharmaceutical and Biomedical Analysis, 2007, 45, 4, 679-687, https://doi.org/10.1016/j.jpba.2007.01.039 . [all data]

Surov, Terekhova, et al., 2009
Surov, Artem O.; Terekhova, Irina V.; Bauer-Brandl, Annette; Perlovich, German L., Thermodynamic and Structural Aspects of Some Fenamate Molecular Crystals, Crystal Growth & Design, 2009, 9, 7, 3265-3272, https://doi.org/10.1021/cg900002q . [all data]

Romero, Bustamante, et al., 2004
Romero, S.; Bustamante, P.; Escalera, B.; Cirri, M.; Mura, P., Characterization of the solid phases of paracetamol and fenamates at equilibrium in saturated solutions, Journal of Thermal Analysis and Calorimetry, 2004, 77, 2, 541-554, https://doi.org/10.1023/B:JTAN.0000038993.61782.ba . [all data]

Bustamante, Peña, et al., 1998
Bustamante, P.; Peña, M.A.; Barra, J., Partial solubility parameters of piroxicam and niflumic acid, International Journal of Pharmaceutics, 1998, 174, 1-2, 141-150, https://doi.org/10.1016/S0378-5173(98)00263-4 . [all data]

Lora-Tamayo, Rams, et al., 1986
Lora-Tamayo, C.; Rams, M.A.; Chacon, J.M.R., Gas Chromatographic Data for 187 Nitrogen- or Phosphorus-Containing Drugs and Metabolites of Toxicological Interest Analysed on Methyl Silicone Capillary Columns, J. Chromatogr., 1986, 374, 73-85, https://doi.org/10.1016/S0378-4347(00)83254-5 . [all data]

Notes

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• Symbols used in this document:
  

  Tfus	Fusion (melting) point
  ΔfusH	Enthalpy of fusion
  ΔsubH	Enthalpy of sublimation
  ΔsubH°	Enthalpy of sublimation at standard conditions
  ΔvapH°	Enthalpy of vaporization at standard conditions

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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