Tolfenamic acid
- Formula: C14H12ClNO2
- Molecular weight: 261.704
- IUPAC Standard InChI: InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
- IUPAC Standard InChIKey: YEZNLOUZAIOMLT-UHFFFAOYSA-N
- CAS Registry Number: 13710-19-5
- Chemical structure:
This structure is also available as a 2d Mol file - Other names: Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]-; Anthranilic acid, N-(3-chloro-o-tolyl)-; N-(3-Chloro-2-methylphenyl)anthranilic acid; N-(3-Chloro-o-tolyl)-anthranilic acid; GEA 6414; N-(2-Methyl-3-chlorophenyl)anthranilic acid; Clotam; Tolfedine; Tolfine; 2-[(3-Chloro-2-methylphenyl)amino]benzoic acid (tolfenamic acid)
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Phase change data
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: William E. Acree, Jr., James S. Chickos
| Quantity | Value | Units | Method | Reference | Comment |
|---|---|---|---|---|---|
| ΔsubH° | 30.7 ± 0.2 | kcal/mol | GS | Surov, Terekhova, et al., 2009 | Based on data from 346. to 373. K. |
Enthalpy of sublimation
| ΔsubH (kcal/mol) | Temperature (K) | Method | Reference | Comment |
|---|---|---|---|---|
| 30.0 ± 0.2 | 360. | GS | Surov, Terekhova, et al., 2009 | Based on data from 346. to 373. K. |
Enthalpy of fusion
| ΔfusH (kcal/mol) | Temperature (K) | Method | Reference | Comment |
|---|---|---|---|---|
| 11.7 | 485.8 | DSC | Surov, Szterner, et al., 2009 | Based on data from yellow crys K. |
| 9.23 | 484.3 | DSC | Surov, Terekhova, et al., 2009 | |
| 9.85 | 485.3 | N/A | Bergström, Wassvik, et al., 2007 |
References
Go To: Top, Phase change data, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Surov, Terekhova, et al., 2009
Surov, Artem O.; Terekhova, Irina V.; Bauer-Brandl, Annette; Perlovich, German L.,
Thermodynamic and Structural Aspects of Some Fenamate Molecular Crystals,
Crystal Growth & Design, 2009, 9, 7, 3265-3272, https://doi.org/10.1021/cg900002q
. [all data]
Surov, Szterner, et al., 2009
Surov, Artem O.; Szterner, Piotr; Zielenkiewicz, Wojciech; Perlovich, German L.,
Thermodynamic and structural study of tolfenamic acid polymorphs,
Journal of Pharmaceutical and Biomedical Analysis, 2009, 50, 5, 831-840, https://doi.org/10.1016/j.jpba.2009.06.045
. [all data]
Bergström, Wassvik, et al., 2007
Bergström, Christel A.S.; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina,
Poorly Soluble Marketed Drugs Display Solvation Limited Solubility,
J. Med. Chem., 2007, 50, 23, 5858-5862, https://doi.org/10.1021/jm0706416
. [all data]
Notes
Go To: Top, Phase change data, References
- Symbols used in this document:
ΔfusH Enthalpy of fusion ΔsubH Enthalpy of sublimation ΔsubH° Enthalpy of sublimation at standard conditions - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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