Ketoprofen

• Formula: C₁₆H₁₄O₃
• Molecular weight: 254.2806
• IUPAC Standard InChI: InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) Copy

  
• IUPAC Standard InChIKey: DKYWVDODHFEZIM-UHFFFAOYSA-N Copy
• CAS Registry Number: 22071-15-4
• Chemical structure:
  This structure is also available as a 2d Mol file
• Other names: Benzeneacetic acid, 3-benzoyl-α-methyl-; Propionic acid, 2-(3-benzoylphenyl)-; Alrheumat; Alrheumun; m-Benzoylhydratropic acid; 3-Benzoylhydratropic acid; 3-Benzoyl-α-methylbenzeneacetic acid; 2-(m-Benzoylphenyl)propionic acid; 2-(3-Benzoylphenyl)propionic acid; Capisten; Fastum; Iso-K; Kefenid; Ketopron; Lertus; Meprofen; Orudis; Oruvail; Profenid; 19583 RP; Dexal; Epatec; Menamin; Orugesic; Oscorel; RP-19583; Toprec; Toprek; (.+/-.)-3-Benzoyl-α-methylbenzeneacetic acid; (.+/-.)-m-Benzoylhydratropic acid; Aneol; Ketoprofene; RU 4733; Racemic ketoprofen; (+)α-(3-benzoylphenyl)propionic acid ((+)-ketoprofen)
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• Information on this page:
  • Phase change data
  • Mass spectrum (electron ionization)
  • References
  • Notes
• Other data available:
  • Gas Chromatography
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of sublimation

Enthalpy of fusion

Mass spectrum (electron ionization)

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Additional Data

References

Go To: Top, Phase change data, Mass spectrum (electron ionization), Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Perlovich, Kurkov, et al., 2003
Perlovich, German L.; Kurkov, Sergey V.; Kinchin, Andrey N.; Bauer-Brandl, Annette, Thermodynamics of solutions IV: Solvation of ketoprofen in comparison with other NSAIDs, J. Pharm. Sci., 2003, 92, 12, 2502-2511, https://doi.org/10.1002/jps.10512 . [all data]

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Wassvik, Holmén, et al., 2008
Wassvik, Carola M.; Holmén, Anders G.; Draheim, Rieke; Artursson, Per; Bergström, Christel A.S., Molecular Characteristics for Solid-State Limited Solubility, J. Med. Chem., 2008, 51, 10, 3035-3039, https://doi.org/10.1021/jm701587d . [all data]

Mura, 1998
Mura, P., Interactions of ketoprofen and ibuprofen with β-cyclodextrins in solution and in the solid state, International Journal of Pharmaceutics, 1998, 166, 2, 189-203, https://doi.org/10.1016/S0378-5173(98)00035-0 . [all data]

Mura, Faucci, et al., 1999
Mura, P.; Faucci, M.T.; Parrini, P.L.; Furlanetto, S.; Pinzauti, S., Influence of the preparation method on the physicochemical properties of ketoprofen--cyclodextrin binary systems, International Journal of Pharmaceutics, 1999, 179, 1, 117-128, https://doi.org/10.1016/S0378-5173(98)00390-1 . [all data]

Espitalier, Biscans, et al., 1995
Espitalier, F.; Biscans, B.; Peyrigain, P. Sere; Laguérie, C., Ternary diagram: alpha-(3-benzoylphenyl)-propionic acid (ketoprofen) in acetone«58872»water mixtures at different temperatures. Experimental data and predicted results, Fluid Phase Equilibria, 1995, 113, 1-2, 151-171, https://doi.org/10.1016/0378-3812(95)02806-8 . [all data]

Notes

Go To: Top, Phase change data, Mass spectrum (electron ionization), References

• Symbols used in this document:
  

  ΔfusH	Enthalpy of fusion
  ΔsubH	Enthalpy of sublimation

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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