Pindolol
- Formula: C14H20N2O2
- Molecular weight: 248.3208
- IUPAC Standard InChI: InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
- IUPAC Standard InChIKey: JZQKKSLKJUAGIC-UHFFFAOYSA-N
- CAS Registry Number: 13523-86-9
- Chemical structure:
This structure is also available as a 2d Mol file or as a computed 3d SD file
The 3d structure may be viewed using Java or Javascript. - Other names: 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-; Calvisken; 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole; 1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol; 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol; LB-46; Prinodolol; 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-; Visken; 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol; Betapindol; Blockin L; Blocklin L; Decreten; Durapindol; Glauco-Visken; Pectobloc; Pinbetol; Pynastin; (.+/-.)-Pindolol; 4-(3-(Isopropylamino)-2-hydroxypropoxy)indole; Carvisken; (±) 1-(1H-indol-4-yloxy)-3-(isopropylamino)-2-propanol (pindolol)
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Phase change data
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: William E. Acree, Jr., James S. Chickos
| Quantity | Value | Units | Method | Reference | Comment |
|---|---|---|---|---|---|
| ΔsubH° | 146.0 ± 1.2 | kJ/mol | GS | Perlovich, Volkova, et al., 2007 | Based on data from 355. to 427. K. |
Enthalpy of fusion
| ΔfusH (kJ/mol) | Temperature (K) | Method | Reference |
|---|---|---|---|
| 60.6 | 423.6 | DSC | Perlovich, Volkova, et al., 2007 |
| 58. | 443.8 | N/A | Nunes, Eusébio, et al., 2004 |
| 57.9 | 442.9 | N/A | Li, Zell, et al., 1999 |
References
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Perlovich, Volkova, et al., 2007
Perlovich, German L.; Volkova, Tatyana V.; Bauer-Brandl, Annette,
Thermodynamic Study of Sublimation, Solubility, Solvation, and Distribution Processes of Atenolol and Pindolol,
Mol. Pharmaceutics, 2007, 4, 6, 929-935, https://doi.org/10.1021/mp070039b
. [all data]
Nunes, Eusébio, et al., 2004
Nunes, Sandra C.C.; Eusébio, M. Ermelinda; Leitão, M. Luísa P.; Redinha, J.S.,
Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol,
International Journal of Pharmaceutics, 2004, 285, 1-2, 13-21, https://doi.org/10.1016/j.ijpharm.2004.07.024
. [all data]
Li, Zell, et al., 1999
Li, Z. Jane; Zell, Mark T.; Munson, Eric J.; Grant, David J.W.,
Characterization of racemic species of chiral drugs using thermal analysis, thermodynamic calculation, and structural studies,
J. Pharm. Sci., 1999, 88, 3, 337-346, https://doi.org/10.1021/js980205u
. [all data]
Notes
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- Symbols used in this document:
ΔfusH Enthalpy of fusion ΔsubH° Enthalpy of sublimation at standard conditions - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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