Griseofulvin

• Formula: C₁₇H₁₇ClO₆
• Molecular weight: 352.766
• IUPAC Standard InChI: InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3 Copy

  
• IUPAC Standard InChIKey: DDUHZTYCFQRHIY-UHFFFAOYSA-N Copy
• CAS Registry Number: 126-07-8
• Chemical structure:
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• Other names: Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-; Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'β-methyl-; (+)-Griseofulvin; Amudane; Curling factor; Fulcin; Fulvicin; Fulvina; Fulvinil; Fulvistatin; Gricin; Grifulin; Grifulvin; Grisactin; Griseofulvin, (+)-; Grisofulvin; Grisovin; Grizeofulvin; Grysio; Lamoryl; Likuden; Likunden; Neo-Fulcin; Poncyl; Spirofulvin; Sporostatin; Biogrisin-FP; 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione; Delmofulvina; Fulcine; Fulvican grisactin; Fulvicin-P/G; Fulvicin-U/F; Fungivin; Greosin; Gresfeed; Grifulvin V; Griscofulvin; Grisefuline; Griseo; Griseofulvin-forte; Griseofulvinum; Grisetin; Gris-PEG; Guservin; Murfulvin; NSC 34533; USAF SC-2; 7-Chloro-2',4,6-trimethoxy-6'β-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione; Sporostatin xan; Xuanjing; Grisovin FP; Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S,6'R)-; Fulvicin Bolus; Polygris; ([1S]-trans-7-chloro-,2',4,6-trimethoxy-6'-methylsprio[benzofuran-2(3H),1'-(2)cyclohexene]-3,4'-dione (griseofulvin)
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• Information on this page:
  • Phase change data
  • References
  • Notes
• Other data available:
  • IR Spectrum
  • Mass spectrum (electron ionization)
  • Gas Chromatography
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Wassvik, Holmén, et al., 2008
Wassvik, Carola M.; Holmén, Anders G.; Draheim, Rieke; Artursson, Per; Bergström, Christel A.S., Molecular Characteristics for Solid-State Limited Solubility, J. Med. Chem., 2008, 51, 10, 3035-3039, https://doi.org/10.1021/jm701587d . [all data]

Grant and Abougela, 1983
Grant, D.J.W.; Abougela, I.K.A., Prediction of the solubility of griseofulvin in glycerides and other solvents of relatively low polarity from simple regular solution theory, International Journal of Pharmaceutics, 1983, 17, 1, 77-89, https://doi.org/10.1016/0378-5173(83)90020-0 . [all data]

Notes

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• Symbols used in this document:
  

  ΔfusH

  Enthalpy of fusion

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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