Ibuprofen

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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

ΔfusH (kJ/mol) Temperature (K) Method Reference Comment
39.5350.4DSCCilurzo, Alberti, et al., 2010 
27.94347.6DSCHong, Hua, et al., 2010 
26.6346.4DSCWassvik, Holmén, et al., 2006 
26.65348.N/AGracin and Rasmuson, 2002See also Xu, Sun, et al., 2004.
25.7350.9DSCLi, Zell, et al., 1999 

Mass spectrum (electron ionization)

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Owner NIST Mass Spectrometry Data Center
Collection (C) 2014 copyright by the U.S. Secretary of Commerce
on behalf of the United States of America. All rights reserved.
Origin NIST Mass Spectrometry Data Center
NIST MS number 352144

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References

Go To: Top, Phase change data, Mass spectrum (electron ionization), Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Cilurzo, Alberti, et al., 2010
Cilurzo, F.; Alberti, E.; Minghetti, P.; Gennari, C.G.M.; Casiraghi, A.; Montanari, L., Effect of drug chirality on the skin permeability of ibuprofen, International Journal of Pharmaceutics, 2010, 386, 1-2, 71-76, https://doi.org/10.1016/j.ijpharm.2009.10.053 . [all data]

Hong, Hua, et al., 2010
Hong, Jindui; Hua, Dan; Wang, Xia; Wang, Hongtao; Li, Jun, Solid-Liquid-Gas Equilibrium of the Ternaries Ibuprofen + Myristic Acid + CO 2 and Ibuprofen + Tripalmitin + CO 2, J. Chem. Eng. Data, 2010, 55, 1, 297-302, https://doi.org/10.1021/je900342a . [all data]

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Gracin and Rasmuson, 2002
Gracin, Sandra; Rasmuson, Åke C., Solubility of Phenylacetic Acid, p -Hydroxyphenylacetic Acid, p -Aminophenylacetic Acid, p -Hydroxybenzoic Acid, and Ibuprofen in Pure Solvents, J. Chem. Eng. Data, 2002, 47, 6, 1379-1383, https://doi.org/10.1021/je0255170 . [all data]

Xu, Sun, et al., 2004
Xu, Fen; Sun, Li-Xian; Tan, Zhi-Cheng; Liang, Jian-Guo; Li, Rui-Lian, Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis, Thermochimica Acta, 2004, 412, 1-2, 33-57, https://doi.org/10.1016/j.tca.2003.08.021 . [all data]

Li, Zell, et al., 1999
Li, Z. Jane; Zell, Mark T.; Munson, Eric J.; Grant, David J.W., Characterization of racemic species of chiral drugs using thermal analysis, thermodynamic calculation, and structural studies, J. Pharm. Sci., 1999, 88, 3, 337-346, https://doi.org/10.1021/js980205u . [all data]


Notes

Go To: Top, Phase change data, Mass spectrum (electron ionization), References