Sulfadiazine

• Formula: C₁₀H₁₀N₄O₂S
• Molecular weight: 250.277
• IUPAC Standard InChI: InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14) Copy

  
• IUPAC Standard InChIKey: SEEPANYCNGTZFQ-UHFFFAOYSA-N Copy
• CAS Registry Number: 68-35-9
• Chemical structure:
  This structure is also available as a 2d Mol file
• Other names: Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-; Sulfanilamide, N1-2-pyrimidinyl-; A-306; Adiazin; Adiazine; Coco-Diazine; Cremodiazine; Debenal; Deltazina; Di-Azo-Mul; Diazin; Diazolone; Diazyl; Eskadiazine; Honey diazine; Lipo-Diazine; Lipo-Levazine; Liquadiazine; Microsulfon; N(Sup1)-2-Pyrimidinylsulfanilamide; N(Sup1)-2-Pyrimidylsulfanilamide; Neazine; Piridisir; Pirimal; Pyrimal; RP 2616; S. N. 112; Sanodiazine; Spofadrizine; Sterazine; Sulfadiazin; Sulfapirimidin; Sulfapyrimidine; Sulfazin; Sulfazine; Sulphadiazine; SDA; Theradiazine; 2-Sulfanilamidopyrimidine; 2-Sulfanilylaminopyrimidine; Codiazine; Cremotres; Metha-Meridiazine; Neotrizine; Palatrize; Pecta-diazine, suspension; Pyrimidine, 2-sulfanilamido-; Quadetts; Quadramoid; Sulfadiazene; Sulfanilamidopyrimidine; Sulfapyrimidin; Sulfatryl; Sulfolex; Sulfonsol; Sulfose; Terfonyl; Thi-Di-Mer; Tri-Sulfameth; Trifonamide; Triple Sulfas; Trisem; Truozine; 2-Sulfapyrimidine; Silvadene; N1-2-Pyrimidylsulfanilamide; N1-2-Pyrimidinylsulfanilamide; Diazovit; 2-(4-Aminobenzenesulfonamido)pyrimidine; Sulfanilamide, N1-2(1H)-pyrimidinylidene-; Sulfadiazina Reig Jofre; 2-(4-Aminobenzenesulfonylamino)pyrimidine; 2-(p-Aminobenzenesulfonamido)pyrimidin; 4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline; Sulphadiazine E; 4-Amino-N-(2-pyrmidinyl)benzene sulfonamide (sulfadiazine)
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• Information on this page:
  • Phase change data
  • Gas Chromatography
  • References
  • Notes
• Other data available:
  • IR Spectrum
  • Mass spectrum (electron ionization)
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

Gas Chromatography

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Normal alkane RI, non-polar column, temperature ramp

View large format table.

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Sunwoo and Eisen, 1971
Sunwoo, C.; Eisen, H., Solubility parameter of selected sulfonamides, J. Pharm Sci., 1971, 60, 2, 238, https://doi.org/10.1002/jps.2600600217 . [all data]

Kofler and Sitte, 1950
Kofler, L.; Sitte, H., Melting Point Determination of Substances with Melt with Decomposition, Monatsh. Chem., 1950, 81, 619. [all data]

Martínez, Ávila, et al., 2003
Martínez, Fleming; Ávila, Carolina M.; Gómez, Alfredo, Thermodynamic study of the solubility of some sulfonamides in cyclohexane, J. Braz. Chem. Soc., 2003, 14, 5, 803-808, https://doi.org/10.1590/S0103-50532003000500016 . [all data]

MartÍnez and GÓmez, 2002
MartÍnez, Fleming; GÓmez, Alfredo, Estimation of the Solubility of Sulfonamides in Aqueous Media from Partition Coefficients and Entropies of Fusion, Physics and Chemistry of Liquids, 2002, 40, 4, 411-420, https://doi.org/10.1080/0031910021000017735 . [all data]

Martin, Wu, et al., 1985
Martin, A.; Wu, P.L.; Velasquez, T., Extended hildebrand solubility approach: Sulfonamides in binary and ternary solvents, J. Pharm. Sci., 1985, 74, 3, 277-282, https://doi.org/10.1002/jps.2600740311 . [all data]

Sunwoo and Eisen, 1971, 2
Sunwoo, Chimin; Eisen, Henry, Solubility parameter of selected sulfonamides, J. Pharm. Sci., 1971, 60, 2, 238-244, https://doi.org/10.1002/jps.2600600217 . [all data]

Roder and Stuthe, 1974
Roder, E.; Stuthe, W., Gas-chromatographisce Bestimmung von Sulfonamiden und ihren N4-Acetyl-Metaboliten aus Blut and Harn, Z. Anal. Chem., 1974, 271, 4, 281-283, https://doi.org/10.1007/BF00432831 . [all data]

Notes

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• Symbols used in this document:
  

  Tfus	Fusion (melting) point
  ΔfusH	Enthalpy of fusion

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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