Lovastatin

• Formula: C₂₄H₃₆O₅
• Molecular weight: 404.5396
• IUPAC Standard InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3 Copy

  
• IUPAC Standard InChIKey: PCZOHLXUXFIOCF-UHFFFAOYSA-N Copy
• CAS Registry Number: 75330-75-5
• Chemical structure:
  This structure is also available as a 2d Mol file
• Other names: Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(R*),3α,7β,8β(2S*,4S*),8aβ]]-; (S)-2-Methylbutyric acid, 8-ester with (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one; Mevacor; Mevinolin; Lovalip; Mevinacor; Mevlor; MK-803; Monacolin K; Sivlor; 8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2-methylbutanoate, (2S)-; 6α-Methylcompactin; Altocor; Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)-; MSD 803; 2-Methylbutanoic acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester (lovastatin)
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• Information on this page:
  • Phase change data
  • References
  • Notes
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Nti-Gyabaah, Chmielowski, et al., 2008
Nti-Gyabaah, J.; Chmielowski, R.; Chan, V.; Chiew, Y.C., Solubility of lovastatin in a family of six alcohols: Ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, and 1-octanol, International Journal of Pharmaceutics, 2008, 359, 1-2, 111-117, https://doi.org/10.1016/j.ijpharm.2008.03.046 . [all data]

Tung, Tabora, et al., 2008
Tung, Hsien-Hsin; Tabora, Jose; Variankaval, Nara; Bakken, Daniel; Chen, Chau-Chyun, Prediction of pharmaceutical solubilityVia NRTL-SAC and COSMO-SAC, J. Pharm. Sci., 2008, 97, 5, 1813-1820, https://doi.org/10.1002/jps.21032 . [all data]

Notes

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• Symbols used in this document:
  

  ΔfusH

  Enthalpy of fusion

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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