Hydrocortisone

• Formula: C₂₁H₃₀O₅
• Molecular weight: 362.4599
• IUPAC Standard InChI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m1/s1 Copy

  
• IUPAC Standard InChIKey: JYGXADMDTFJGBT-NDNUHCHRSA-N Copy
• CAS Registry Number: 50-23-7
• Chemical structure:
  This structure is also available as a 2d Mol file or as a computed 3d SD file
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• Stereoisomers:
  • 11Beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
• Other names: Hydroxycortisone; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11β)-; Cortisol; anti-Inflammatory hormone; Cobadex; Cort-Dome; Cortanal; Cortef; Cortenema; Corticreme; Cortifan; Cortiment; Cortispray; Cortonema; Cortril; Dihydrocostisone; Domolene-HC; Efcorbin; Epiderm H; Esiderm H; Ficortril; Genacort; Heb-Cort; Hidro-Colisona; Hycort; Hycortol; Hycortole; Hydrasson; Hydro-Adreson; Hydrocorticosterone; Hydrocortisone alcohol; Hydrocortisyl; Hydrocortone; Hytone lotion; HC; Incortin-H; Kendall's Compound F; NSC 10483; Optef; Otosone-F; Permicort; Polcort H; Reichstein's Substance M; Scheroson F; Signef; Tarcortin; Texacort lotion 25; Topicort; Traumaide; 11β-Hydroxycortisone; 17α-Hydroxycorticosterone; 17-Hydroxycorticosterone; 4-Pregnen-11β,17α,21-triol-3,20-dione; Aeroseb HC; Ala-Scalp; Alacort; Barseb HC; Cetacort; Cleiton; Compound F; Compound F (kendall); Cortisol alcohol; Cortolotion; Cortoxide; Cremesone; Delacort; Dermacort; Dermolate; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Fiocortril; H-Cort; Hydro-colisona; Hydrocortisone free alcohol; Hydrocortistab; Hytone; Incortin-hydrogen; Komed HC; Maintasone; Pregn-4-ene-3,20-dione, 11β,17,21-trihydroxy-; Proctocort; Rectoid; 11β-Hydrocortisone; 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione; 4-Pregnene-11β,17α,21-triol-3,20-dione; Acticort; CaldeCort Spray; Lacticare-HC; Nutracort; Penecort; 11,17,21-Trihydroxypregn-4-ene-3,20-dione, (11β)-; 11β,17,21-trihydroxyprogesterone; Dioderm; Anflam; Dermocortal; Zenoxone; U 1851; Medicort; Mildison; 11Beta,17,21-trihydroxy progesterone; Cor-Tar-Quin (Salt/Mix); Cort-Quin (Salt/Mix); Cortisporin (Salt/Mix); Drotic (Salt/Mix); Neo-Cort-Dome (Salt/Mix); Nystaform-HC (Salt/Mix); Otalgine (Salt/Mix); Otic-Neo-Cort-Dome (Salt/Mix); Otobiotic (Salt/Mix); Otocort (Salt/Mix); Pediotic Suspension (Salt/Mix); Racet (Salt/Mix); Vioform-Hydrocortisone (Salt/Mix); VoSol HC (Salt/Mix); Vytone (Salt/Mix); Alphaderm (Salt/Mix)
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• Information on this page:
  • Condensed phase thermochemistry data
  • Phase change data
  • IR Spectrum
  • Mass spectrum (electron ionization)
  • UV/Visible spectrum
  • References
  • Notes
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Condensed phase thermochemistry data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein

Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

IR Spectrum

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: Coblentz Society, Inc.

Condensed Phase Spectrum

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Notice: Except where noted, spectra from this collection were measured on dispersive instruments, often in carefully selected solvents, and hence may differ in detail from measurements on FTIR instruments or in other chemical environments. More information on the manner in which spectra in this collection were collected can be found here.

Notice: Concentration information is not available for this spectrum and, therefore, molar absorptivity values cannot be derived.

Additional Data

Mass spectrum (electron ionization)

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Additional Data

UV/Visible spectrum

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: Victor Talrose, Alexander N. Yermakov, Alexy A. Usov, Antonina A. Goncharova, Axlexander N. Leskin, Natalia A. Messineva, Natalia V. Trusova, Margarita V. Efimkina

Spectrum

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Additional Data

References

Go To: Top, Condensed phase thermochemistry data, Phase change data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Paoli, Garrigues, et al., 1969
Paoli, D.; Garrigues, J.-C.; Patin, H., Combustion microcalorimetry: application to steroids, C. R. Acad. Sci. Paris, 1969, 268, 780-783. [all data]

Regosz, Chmielewska, et al., 1994
Regosz, A.; Chmielewska, A.; Pelplinska, T.; Kowalski, P., Prediction of the solubility of steroid hormones, Pharmazie, 1994, 49, 5, 371. [all data]

Lang (editor), 1966
Lang (editor), L., Absorption Spectra in the Ultraviolet and Visible Region, 1966, 7, 181. [all data]

Notes

Go To: Top, Condensed phase thermochemistry data, Phase change data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References

• Symbols used in this document:
  

  ΔcH°solid	Enthalpy of combustion of solid at standard conditions
  ΔfusH	Enthalpy of fusion

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
• The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database.
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