10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,β-trimethyl-

Formula: C₁₉H₂₄N₂OS
Molecular weight: 328.472
IUPAC Standard InChI: InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3
IUPAC Standard InChIKey: VRQVVMDWGGWHTJ-UHFFFAOYSA-N
CAS Registry Number: 851-68-3
Chemical structure:
This structure is also available as a 2d Mol file
Stereoisomers:
- Methotrimeprazine
Other names: Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-; 10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine; (.+/-.)-Methotrimeprazine; dl-Methotrimeprazine; 2-Methoxy-N,N,β-trimethyl-10H-phenothiazine-10-propylamine; 2-Methoxy-N,N,beta-trimethyl-10H-phenothiazine-10-propylamine; Methotrimeprazine; Levomepromazine; Levomepropazine
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Information on this page:
Other data available:
- Mass spectrum (electron ionization)
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Gas Chromatography

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Kovats' RI, non-polar column, isothermal

Column type	Active phase	Temperature (C)	I	Reference	Comment
Packed	SE-30	240.	2521.	Musumarra, Scarlata, et al., 1987	N2, 1% se-30 on Anachrom ABS(80-100mesh); Column length: 2. m
Capillary	SPB-1	250.	2557.	Lora-Tamayo, Rams, et al., 1986	He; Column length: 25. m; Column diameter: 0.20 mm

Kovats' RI, non-polar column, temperature ramp

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Column type	Active phase	I	Reference	Comment
Capillary	SE-30	2532.	Schepers, Wijsbeek, et al., 1982	25. m/0.49 mm/1.14 μm, 100. C @ 2. min, 8. K/min, 275. C @ 15. min

Van Den Dool and Kratz RI, non-polar column, temperature ramp

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Column type	Active phase	I	Reference	Comment
Capillary	CBP-1	2512.	Oyama, Sano, et al., 1987	N2, 6. K/min; Column length: 12. m; Column diameter: 0.53 mm; T_start: 120. C; T_end: 250. C
Packed	Methyl Silicone	2510.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2536.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2535.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2535.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2538.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2539.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2540.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2540.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2540.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2540.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2542.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2542.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2542.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2542.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2540.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2540.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2542.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2542.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2543.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2545.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2545.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2545.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2547.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2550.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2530.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2530.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2532.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2535.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2535.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2535.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2537.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2537.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2537.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2537.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Packed	Methyl Silicone	2540.	Bogusz, Wijsbeek, et al., 1985	120. C @ 4. min, 7. K/min, 290. C @ 10. min
Capillary	DB-1	2511.	Perrigo, Peel, et al., 1985	15. m/0.32 mm/0.25 μm, He, 8. K/min, 280. C @ 5. min; T_start: 120. C
Capillary	DB-1	2511.	Perrigo, Ballantyne, et al., 1984	15. m/0.25 mm/0.25 μm, He, 8. K/min, 280. C @ 5. min; T_start: 120. C
Capillary	SE-30	2490.	Anderson and Stafford, 1983	15. m/0.25 mm/0.25 μm, He, 5. K/min; T_start: 100. C; T_end: 295. C
Packed	SE-30	2515.	Perrigo and Peel, 1981	N2, Chromosorb W, 130. C @ 2. min, 8. K/min, 290. C @ 8. min; Column length: 1.8 m

Normal alkane RI, non-polar column, isothermal

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Column type	Active phase	Temperature (C)	I	Reference	Comment
Packed	OV-1	240.	2543.	Courtot, 1976	Supelcoport (100-120 mesh); Column length: 2. m
Packed	OV-1	260.	2563.	Courtot, 1976	Supelcoport (100-120 mesh); Column length: 2. m

Normal alkane RI, non-polar column, temperature ramp

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Column type	Active phase	I	Reference	Comment
Packed	OV-101	2542.	Maurer and Pfleger, 1984	N2, Chromosorb G HP, 20. K/min, 310. C @ 3. min; Column length: 0.6 m; T_start: 100. C
Packed	SE-30	2540.	Marozzi, Gambaro, et al., 1982	Gas Chrom P, 5. K/min; Column length: 2. m; T_start: 150. C; T_end: 300. C

Normal alkane RI, non-polar column, custom temperature program

View large format table.

Column type	Active phase	I	Reference	Comment
Packed	OV-101	2569.	Buydens, Massart, et al., 1985	Gas Chrom Q; Column length: 2. m; Program: not specified
Other	Methyl Silicone	2514.	Ardrey and Moffat, 1981	Program: not specified

References

Go To: Top, Gas Chromatography, Notes

Musumarra, Scarlata, et al., 1987
Musumarra, G.; Scarlata, G.; Romano, G.; Cappello, G.; Clementi, S.; Giulietti, G., Qualitative organic analysis. Part 2. Identification of drugs by principal components analysis of standardized TLC data in four eluent systems and of retention indices on SE 30, J. Anal. Toxicol., 1987, 11, 4, 154-163, https://doi.org/10.1093/jat/11.4.154 . [all data]

Lora-Tamayo, Rams, et al., 1986
Lora-Tamayo, C.; Rams, M.A.; Chacon, J.M.R., Gas Chromatographic Data for 187 Nitrogen- or Phosphorus-Containing Drugs and Metabolites of Toxicological Interest Analysed on Methyl Silicone Capillary Columns, J. Chromatogr., 1986, 374, 73-85, https://doi.org/10.1016/S0378-4347(00)83254-5 . [all data]

Schepers, Wijsbeek, et al., 1982
Schepers, P.; Wijsbeek, J.; Franke, J.P.; de Zeeuw, R.A., Applicability of capillary gas chromatography to substance identification in toxicology by means of retention indices, J. Forensic Sci., 1982, 27, 1, 49-60. [all data]

Oyama, Sano, et al., 1987
Oyama, N.; Sano, T.; Syoyama, M.; Maeda, K., Studies on systematic analysis of poisonous compounds in forensic chemistry. II. Application of capillary column gas chromatography to substance identification by means of retention indices, Eisei Kagaku, 1987, 33, 5, 342-348, https://doi.org/10.1248/jhs1956.33.342 . [all data]

Bogusz, Wijsbeek, et al., 1985
Bogusz, M.; Wijsbeek, J.; Franke, J.P.; de Zeeuw, R.A.; Gierz, J., Impact of biological matrix, drug concentration, and method of isolation on detectability and variability of retention index values in gas chromatography, J. Anal. Toxicol., 1985, 9, 2, 49-54, https://doi.org/10.1093/jat/9.2.49 . [all data]

Perrigo, Peel, et al., 1985
Perrigo, B.J.; Peel, H.W.; Ballantyne, D.J., Use of Dual-Column Fused-Silica Capillary Gas Chromatography in Combination with Detector Response Factors for Analytical Toxicology., J. Chromatogr., 1985, 341, 81-88, https://doi.org/10.1016/S0378-4347(00)84011-6 . [all data]

Perrigo, Ballantyne, et al., 1984
Perrigo, B.J.; Ballantyne, D.J.; Peel, H.W., Condierations in developing a data base for drugs on a DBI capillary column, J. Can. Soc. Forensic Sci., 1984, 17, 2, 41-49, https://doi.org/10.1080/00085030.1984.10757360 . [all data]

Anderson and Stafford, 1983
Anderson, W.H.; Stafford, D.T., Applications of capillary gas chromatography in routine toxicological analyses, J. Hi. Res. Chromatogr. Chromatogr. Comm., 1983, 6, 5, 247-254, https://doi.org/10.1002/jhrc.1240060506 . [all data]

Perrigo and Peel, 1981
Perrigo, B.J.; Peel, H.W., The use of retention indices and temperature-programmed gas chromatography in analytical toxicology, J. Chromatogr. Sci., 1981, 19, 5, 219-226, https://doi.org/10.1093/chromsci/19.5.219 . [all data]

Courtot, 1976
Courtot, D., Research and identification of tranquillizers - use of retention index, J. Sports Med., 1976, 10, 3, 143-146, https://doi.org/10.1136/bjsm.10.3.143 . [all data]

Maurer and Pfleger, 1984
Maurer, H.; Pfleger, K., Screening procedure for detection of phenothiazine and analogous neuroleptics and their metabolites in urine using a computerized gas chromatographic-mass spectrometric technique, J. Chromatogr., 1984, 306, 125-145, https://doi.org/10.1016/S0378-4347(00)80876-2 . [all data]

Marozzi, Gambaro, et al., 1982
Marozzi, E.; Gambaro, V.; Saligari, E.; Mariani, R.; Lodi, F., Use of the retention index in gas chromatographic studies of drugs, J. Anal. Toxicol., 1982, 6, 4, 185-192, https://doi.org/10.1093/jat/6.4.185 . [all data]

Buydens, Massart, et al., 1985
Buydens, L.; Massart, D.L.; Geerlings, P., Relationship Between Gas Chromatographic Behavior and Topological, Physicochemical, and Quantum Chemically Calculated Charge Parameters for Neuroleptica, J. Chromatogr. Sci., 1985, 23, 7, 304-307, https://doi.org/10.1093/chromsci/23.7.304 . [all data]

Ardrey and Moffat, 1981
Ardrey, R.E.; Moffat, A.C., Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase, J. Chromatogr., 1981, 220, 3, 195-252, https://doi.org/10.1016/S0021-9673(00)81925-1 . [all data]

Notes

Go To: Top, Gas Chromatography, References

Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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