Lorazepam
- Formula: C15H11Cl2N2O2
- Molecular weight: 322.166
- IUPAC Standard InChI: InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
- IUPAC Standard InChIKey: DIWRORZWFLOCLC-UHFFFAOYSA-N
- CAS Registry Number: 846-49-1
- Chemical structure:
This structure is also available as a 2d Mol file or as a computed 3d SD file
The 3d structure may be viewed using Java or Javascript. - Other names: 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-; 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-; o-Chlorooxazepam; o-Chloroxazepam; Tavor; Temesta; Wy 4036; Ativan; 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; Almazine; 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one; Emotival; Lorax; Lorsilan; Psicopax; Wypax; (.+/-.)-Lorazepam; Pro dorm; Punktyl; Quait; Securit; Sedatival; Sedazin; Somagerol; Anxiedin; Anxira; Anzepam; Aplacasse; Apo-Lorazepam; Aripax; Azurogen; Bonatranquan; Bonton; Delormetazepam; Demethyllormetazepam; Duralozam; Efasedan; Equitam; Kalmalin; Larpose; Laubeel; Lorabenz; Loram; Lorapam; Lorat; Lorazene; Lorazep; Lorazin; Lorenin; Loridem; Lorsedal; Lozepam; Merlit; Nervistop L; Norlormetazepam; Novhepar; NSC 289758; Orfidal; Renaquil; Rocosgen; Sedizepan; Sidenar; Silence; Stapam; Titus; Tranqipam; Trapax; Upan; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one ((±)lorazepam)
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Phase change data
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: William E. Acree, Jr., James S. Chickos
Enthalpy of fusion
| ΔfusH (kcal/mol) | Temperature (K) | Method | Reference |
|---|---|---|---|
| 18.0 | 453.2 | DSC | Wassvik, Holmén, et al., 2008 |
| 22.12 | 446.5 | DSC | Verheyen, Augustijns, et al., 2001 |
References
Go To: Top, Phase change data, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Wassvik, Holmén, et al., 2008
Wassvik, Carola M.; Holmén, Anders G.; Draheim, Rieke; Artursson, Per; Bergström, Christel A.S.,
Molecular Characteristics for Solid-State Limited Solubility,
J. Med. Chem., 2008, 51, 10, 3035-3039, https://doi.org/10.1021/jm701587d
. [all data]
Verheyen, Augustijns, et al., 2001
Verheyen, S.; Augustijns, P.; Kinget, R.; Van den Mooter, G.,
Determination of partial solubility parameters of five benzodiazepines in individual solvents,
International Journal of Pharmaceutics, 2001, 228, 1-2, 199-207, https://doi.org/10.1016/S0378-5173(01)00838-9
. [all data]
Notes
Go To: Top, Phase change data, References
- Symbols used in this document:
ΔfusH Enthalpy of fusion - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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