Trimethoprim

• Formula: C₁₄H₁₈N₄O₃
• Molecular weight: 290.3177
• IUPAC Standard InChI: InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) Copy

  
• IUPAC Standard InChIKey: IEDVJHCEMCRBQM-UHFFFAOYSA-N Copy
• CAS Registry Number: 738-70-5
• Chemical structure:
  This structure is also available as a 2d Mol file
• Other names: 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-; Pyrimidine, 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-; BW 56-72; NIH 204; Syraprim; 2,4-Diamino-5-(3,4,5-Trimethoxybenzyl)pyrimidine; Bactramin; Monotrim; Monotrimin; Proloprim; Trimopan; Trimpex; Veltrim; 5-(3,4,5-Trimethoxybenzyl)-2,4-diaminopyrimidine; Monoprim; NSC-106568; Tiempe; Trimanyl; Trimethopriom; Wellcoprim; 2,4-Diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine; Trimethioprim; Trimetoprim; 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine; Instalac; Trimogal; Uretrim; Triprim; 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine (trimethoprim)
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• Information on this page:
  • Phase change data
  • Mass spectrum (electron ionization)
  • Gas Chromatography
  • References
  • Notes
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

Mass spectrum (electron ionization)

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Additional Data

Gas Chromatography

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Kovats' RI, non-polar column, isothermal

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Van Den Dool and Kratz RI, non-polar column, temperature ramp

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References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Issa, El-Ansary, et al., 1998
Issa, Y.M.; El-Ansary, A.L.; Selim, W., Enthalpimetric Determination of Sulfa Drugs in Pure Form and Pharmaceutical Formulations, Analytical Letters, 1998, 31, 1, 131-146, https://doi.org/10.1080/00032719808001838 . [all data]

Lora-Tamayo, Rams, et al., 1986
Lora-Tamayo, C.; Rams, M.A.; Chacon, J.M.R., Gas Chromatographic Data for 187 Nitrogen- or Phosphorus-Containing Drugs and Metabolites of Toxicological Interest Analysed on Methyl Silicone Capillary Columns, J. Chromatogr., 1986, 374, 73-85, https://doi.org/10.1016/S0378-4347(00)83254-5 . [all data]

Christ, Noomano, et al., 1988
Christ, D.W.; Noomano, P.; Rosas, M.; Rhone, D., Retention indices by wide-bore capillary gas chromatography with nitrogen-phosphorus detection, J. Anal. Toxicol., 1988, 12, 2, 84-88, https://doi.org/10.1093/jat/12.2.84 . [all data]

Notes

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• Symbols used in this document:
  

  ΔfusH

  Enthalpy of fusion

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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