Sulfadiazine
- Formula: C10H10N4O2S
- Molecular weight: 250.277
- IUPAC Standard InChI: InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
- IUPAC Standard InChIKey: SEEPANYCNGTZFQ-UHFFFAOYSA-N
- CAS Registry Number: 68-35-9
- Chemical structure:
This structure is also available as a 2d Mol file - Other names: Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-; Sulfanilamide, N1-2-pyrimidinyl-; A-306; Adiazin; Adiazine; Coco-Diazine; Cremodiazine; Debenal; Deltazina; Di-Azo-Mul; Diazin; Diazolone; Diazyl; Eskadiazine; Honey diazine; Lipo-Diazine; Lipo-Levazine; Liquadiazine; Microsulfon; N(Sup1)-2-Pyrimidinylsulfanilamide; N(Sup1)-2-Pyrimidylsulfanilamide; Neazine; Piridisir; Pirimal; Pyrimal; RP 2616; S. N. 112; Sanodiazine; Spofadrizine; Sterazine; Sulfadiazin; Sulfapirimidin; Sulfapyrimidine; Sulfazin; Sulfazine; Sulphadiazine; SDA; Theradiazine; 2-Sulfanilamidopyrimidine; 2-Sulfanilylaminopyrimidine; Codiazine; Cremotres; Metha-Meridiazine; Neotrizine; Palatrize; Pecta-diazine, suspension; Pyrimidine, 2-sulfanilamido-; Quadetts; Quadramoid; Sulfadiazene; Sulfanilamidopyrimidine; Sulfapyrimidin; Sulfatryl; Sulfolex; Sulfonsol; Sulfose; Terfonyl; Thi-Di-Mer; Tri-Sulfameth; Trifonamide; Triple Sulfas; Trisem; Truozine; 2-Sulfapyrimidine; Silvadene; N1-2-Pyrimidylsulfanilamide; N1-2-Pyrimidinylsulfanilamide; Diazovit; 2-(4-Aminobenzenesulfonamido)pyrimidine; Sulfanilamide, N1-2(1H)-pyrimidinylidene-; Sulfadiazina Reig Jofre; 2-(4-Aminobenzenesulfonylamino)pyrimidine; 2-(p-Aminobenzenesulfonamido)pyrimidin; 4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline; Sulphadiazine E; 4-Amino-N-(2-pyrmidinyl)benzene sulfonamide (sulfadiazine)
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Phase change data
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos
| Quantity | Value | Units | Method | Reference | Comment |
|---|---|---|---|---|---|
| Tfus | 538.8 | K | N/A | Sunwoo and Eisen, 1971 | Uncertainty assigned by TRC = 0.5 K; TRC |
| Tfus | 534. | K | N/A | Kofler and Sitte, 1950 | Uncertainty assigned by TRC = 3. K; with "hot stage"; TRC |
| Tfus | 531. | K | N/A | Kofler and Sitte, 1950 | Uncertainty assigned by TRC = 4. K; under a microscope; TRC |
Enthalpy of fusion
| ΔfusH (kJ/mol) | Temperature (K) | Method | Reference | Comment |
|---|---|---|---|---|
| 44.3 | 532.7 | DSC | Martínez, Ávila, et al., 2003 | See also MartÍnez and GÓmez, 2002.; AC |
| 44.3 | 520.4 | N/A | Martin, Wu, et al., 1985 | AC |
| 31.2 | 538.7 | DTA | Sunwoo and Eisen, 1971, 2 | AC |
References
Go To: Top, Phase change data, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Sunwoo and Eisen, 1971
Sunwoo, C.; Eisen, H.,
Solubility parameter of selected sulfonamides,
J. Pharm Sci., 1971, 60, 2, 238, https://doi.org/10.1002/jps.2600600217
. [all data]
Kofler and Sitte, 1950
Kofler, L.; Sitte, H.,
Melting Point Determination of Substances with Melt with Decomposition,
Monatsh. Chem., 1950, 81, 619. [all data]
Martínez, Ávila, et al., 2003
Martínez, Fleming; Ávila, Carolina M.; Gómez, Alfredo,
Thermodynamic study of the solubility of some sulfonamides in cyclohexane,
J. Braz. Chem. Soc., 2003, 14, 5, 803-808, https://doi.org/10.1590/S0103-50532003000500016
. [all data]
MartÍnez and GÓmez, 2002
MartÍnez, Fleming; GÓmez, Alfredo,
Estimation of the Solubility of Sulfonamides in Aqueous Media from Partition Coefficients and Entropies of Fusion,
Physics and Chemistry of Liquids, 2002, 40, 4, 411-420, https://doi.org/10.1080/0031910021000017735
. [all data]
Martin, Wu, et al., 1985
Martin, A.; Wu, P.L.; Velasquez, T.,
Extended hildebrand solubility approach: Sulfonamides in binary and ternary solvents,
J. Pharm. Sci., 1985, 74, 3, 277-282, https://doi.org/10.1002/jps.2600740311
. [all data]
Sunwoo and Eisen, 1971, 2
Sunwoo, Chimin; Eisen, Henry,
Solubility parameter of selected sulfonamides,
J. Pharm. Sci., 1971, 60, 2, 238-244, https://doi.org/10.1002/jps.2600600217
. [all data]
Notes
Go To: Top, Phase change data, References
- Symbols used in this document:
Tfus Fusion (melting) point ΔfusH Enthalpy of fusion - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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