Tolbutamide

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Phase change data

Go To: Top, IR Spectrum, Mass spectrum (electron ionization), References, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos

Quantity Value Units Method Reference Comment
Tfus400.KN/AGrady, Hays, et al., 1973Uncertainty assigned by TRC = 1. K; TRC

Enthalpy of fusion

ΔfusH (kJ/mol) Temperature (K) Method Reference Comment
27.2400.2DSCKimura, Hirayama, et al., 1999AC
25.61404.8N/AMartin and Miralles, 1982AC

In addition to the Thermodynamics Research Center (TRC) data available from this site, much more physical and chemical property data is available from the following TRC products:


IR Spectrum

Go To: Top, Phase change data, Mass spectrum (electron ionization), References, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: Coblentz Society, Inc.

Condensed Phase Spectrum

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IR spectrum
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Notice: Except where noted, spectra from this collection were measured on dispersive instruments, often in carefully selected solvents, and hence may differ in detail from measurements on FTIR instruments or in other chemical environments. More information on the manner in which spectra in this collection were collected can be found here.

Notice: Concentration information is not available for this spectrum and, therefore, molar absorptivity values cannot be derived.

Additional Data

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Owner COBLENTZ SOCIETY
Collection (C) 2018 copyright by the U.S. Secretary of Commerce
on behalf of the United States of America. All rights reserved.
Origin ABBOTT LABORATORIES - WASHBURN
Source reference COBLENTZ NO. 3486
Date Not specified, most likely prior to 1970
Name(s) 1-(([(butylamino)carbonyl]amino)sulfonyl)-4-methylbenzene
State SOLUTION (7% IN CHCl3)
Instrument PERKIN-ELMER
Path length 0.010 CM
INACTIVE (CHCl3) AROUND 750 CM-1
Resolution 4
Sampling procedure TRANSMISSION
Data processing DIGITIZED BY NIST FROM HARD COPY (FROM TWO SEGMENTS)

This IR spectrum is from the Coblentz Society's evaluated infrared reference spectra collection.


Mass spectrum (electron ionization)

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Mass spectrum
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Additional Data

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Due to licensing restrictions, this spectrum cannot be downloaded.

Owner NIST Mass Spectrometry Data Center
Collection (C) 2014 copyright by the U.S. Secretary of Commerce
on behalf of the United States of America. All rights reserved.
Origin Japan AIST/NIMC Database- Spectrum MS-IW-6771
NIST MS number 242090

All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library. Please see the following for information about the library and its accompanying search program.


References

Go To: Top, Phase change data, IR Spectrum, Mass spectrum (electron ionization), Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Grady, Hays, et al., 1973
Grady, L.T.; Hays, S.E.; King, R.H.; Klein, H.R.; Mader, W.J.; Wyatt, D.K.; Zimmere, R.O., Drug purity profiles, J. Pharm. Sci., 1973, 62, 459. [all data]

Kimura, Hirayama, et al., 1999
Kimura, Kenya; Hirayama, Fumitoshi; Uekama, Kaneto, Characterization of tolbutamide polymorphs (burger's forms II and IV) and polymorphic transition behavior, J. Pharm. Sci., 1999, 88, 4, 385-391, https://doi.org/10.1021/js980376z . [all data]

Martin and Miralles, 1982
Martin, A.; Miralles, M.J., Extended hildebrand solubility approach: Solubility of tolbutamide, acetohexamide, and sulfisomidine in binary solvent mixtures, J. Pharm. Sci., 1982, 71, 4, 439-442, https://doi.org/10.1002/jps.2600710416 . [all data]


Notes

Go To: Top, Phase change data, IR Spectrum, Mass spectrum (electron ionization), References