Tolbutamide

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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos

Quantity Value Units Method Reference Comment
Tfus400.KN/AGrady, Hays, et al., 1973Uncertainty assigned by TRC = 1. K; TRC

Enthalpy of fusion

ΔfusH (kcal/mol) Temperature (K) Method Reference Comment
6.50400.2DSCKimura, Hirayama, et al., 1999AC
6.121404.8N/AMartin and Miralles, 1982AC

In addition to the Thermodynamics Research Center (TRC) data available from this site, much more physical and chemical property data is available from the following TRC products:


References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Grady, Hays, et al., 1973
Grady, L.T.; Hays, S.E.; King, R.H.; Klein, H.R.; Mader, W.J.; Wyatt, D.K.; Zimmere, R.O., Drug purity profiles, J. Pharm. Sci., 1973, 62, 459. [all data]

Kimura, Hirayama, et al., 1999
Kimura, Kenya; Hirayama, Fumitoshi; Uekama, Kaneto, Characterization of tolbutamide polymorphs (burger's forms II and IV) and polymorphic transition behavior, J. Pharm. Sci., 1999, 88, 4, 385-391, https://doi.org/10.1021/js980376z . [all data]

Martin and Miralles, 1982
Martin, A.; Miralles, M.J., Extended hildebrand solubility approach: Solubility of tolbutamide, acetohexamide, and sulfisomidine in binary solvent mixtures, J. Pharm. Sci., 1982, 71, 4, 439-442, https://doi.org/10.1002/jps.2600710416 . [all data]


Notes

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