Hydrochlorothiazide
- Formula: C7H8ClN3O4S2
- Molecular weight: 297.739
- IUPAC Standard InChI: InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
- IUPAC Standard InChIKey: JZUFKLXOESDKRF-UHFFFAOYSA-N
- CAS Registry Number: 58-93-5
- Chemical structure:
This structure is also available as a 2d Mol file - Other names: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide; Aquarills; Aquarius; Chlorosulthiadil; Dichlotiazid; Dichlotride; Diclotride; Dihydrochlorothiazid; Dihydrochlorothiazide; Dihydrochlorothiazidum; Disalunil; Drenol; Esidrex; Esidrix; Hidril; Hidrochlortiazid; Hidrotiazida; Hydril; Hydro-Aquil; Hydro-Diuril; Hydrochlorothiazid; Hydrochlorthiazide; Hydrodiuretic; Hydrosaluric; Hypothiazid; Hypothiazide; HCTZ; HCZ; Idrotiazide; Megadiuril; Nefrix; Oretic; Su 5879; Vetidrex; 3,4-Dihydrochlorothiazide; Dyazide; Jen-Diril; Maschitt; Newtolide; NCI-C55925; Servithiazid; Thiuretic; Thlaretic; 3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide; 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; Bremil; Chlorsulfonamidodihydrobenzothiadiazine dioxide; Chlorzide; Cidrex; Dichlorosal; Direma; Fluvin; Hidroronol; Hydrothide; Ivaugan; Neo-codema; Neoflumen; Panurin; Ro-hydrazide; Thiaretic; Urodiazin; Zide; Hydrozide; Dihydrochlorurite; Dihydrochlorurit; Acuretic; Apresazide; Caplaril; H.H. 25/25; H.H. 50/50; Lopressor HCT; Lotensin HCT; Moduretic; Timolide; Unipres; Vaseretic; Ziac; 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; 2H-1,2,4-Benzothiadiazine, 6-chloro-3,4-dihydro-7-sulfamoyl-2, 1,1-dioxide; Thiazide, hydrochloro-; 6-Chloro-7-sulfamoyl-3,4-dihydrobenzo-1,2,4-thiadiazine-1,1-dioxide; Carozide; Aquazide; Hydrocot; Hydrochlorzide; Urirex; Idrodiuvis; Microzide; Manschitt; H-1,2,4-benzothiadiazine, 6-chloro-3,4-dihydro-7-sulfamoyl-2, 1,1-dioxide; 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide (hydrochlorthiazide)
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Phase change data
Go To: Top, IR Spectrum, Mass spectrum (electron ionization), References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: William E. Acree, Jr., James S. Chickos
Enthalpy of fusion
| ΔfusH (kJ/mol) | Temperature (K) | Method | Reference |
|---|---|---|---|
| 33.6 | 540.8 | DSC | Wassvik, Holmén, et al., 2006 |
| 30.96 | 547.2 | N/A | Hancock and Parks, 2000 |
IR Spectrum
Go To: Top, Phase change data, Mass spectrum (electron ionization), References, Notes
Data compiled by: Coblentz Society, Inc.
- SOLID (1.5 mg / 350 mg KBr DISC) VS AIR $$ SEE SPECTRUM NO 5069 FOR "PRISM" SPECTRUM; BECKMAN IR-12 (GRATING); DIGITIZED BY COBLENTZ SOCIETY (BATCH I) FROM HARD COPY; 2 cm-1 resolution
- SOLID (KBr DISC); PERKIN-ELMER 21 (GRATING); DIGITIZED BY COBLENTZ SOCIETY (BATCH I) FROM HARD COPY; 2 cm-1 resolution
- SOLID (NUJOL MULL); PERKIN-ELMER; DIGITIZED BY NIST FROM HARD COPY (FROM TWO SEGMENTS); 4 cm-1 resolution
- SOLID (SPLIT MULL) $$ SEE SPECTRUM NO 5069 FOR "PRISM" SPECTRUM; BECKMAN IR-12 (GRATING); DIGITIZED BY COBLENTZ SOCIETY (BATCH I) FROM HARD COPY; 2 cm-1 resolution
Mass spectrum (electron ionization)
Go To: Top, Phase change data, IR Spectrum, References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
Spectrum
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Additional Data
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| Owner | NIST Mass Spectrometry Data Center Collection (C) 2014 copyright by the U.S. Secretary of Commerce on behalf of the United States of America. All rights reserved. |
|---|---|
| Origin | EQUINE DRUG TESTING PROG. J.D.HENION,ETAL CORNELL U, ITHACA, NY |
| NIST MS number | 74591 |
References
Go To: Top, Phase change data, IR Spectrum, Mass spectrum (electron ionization), Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per,
Contribution of solid-state properties to the aqueous solubility of drugs,
European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013
. [all data]
Hancock and Parks, 2000
Hancock, Bruno C.; Parks, Michael,
Organometallics, 2000, 17, 4, 397-404, https://doi.org/10.1023/A:1007516718048
. [all data]
Notes
Go To: Top, Phase change data, IR Spectrum, Mass spectrum (electron ionization), References
- Symbols used in this document:
ΔfusH Enthalpy of fusion - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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