Progesterone
- Formula: C21H30O2
- Molecular weight: 314.4617
- IUPAC Standard InChI: InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m1/s1
- IUPAC Standard InChIKey: RJKFOVLPORLFTN-RLLAOZKESA-N
- CAS Registry Number: 57-83-0
- Chemical structure:
This structure is also available as a 2d Mol file - Other names: Pregn-4-ene-3,20-dione; δ(Sup4)-pregnene-3,20-dione; Agolutin; Bio-luton; Corlutin; Corlutina; Corluvite; Corporin; Corpus luteum hormone; Flavolutan; Fologenon; Gesterol; Gestone; Gestormone; Gestron; Glanducorpin; Gynlutin; Gynolutone; Hormoflaveine; Hormoluton; Lipo-lutin; Lucorteum sol; Luteal hormone; Luteinique; Luteocrin normale; Luteodyn; Luteogan; Luteohormone; Luteol; Luteopur; Luteosan; Luteostab; Luteovis; Lutex; Lutidon; Lutin; Lutociclina; Lutocyclin; Lutocyclin M; Lutocylin; Lutoform; Lutogyl; Lutren; Lutromone; Nalutron; Percutacrine luteinique; Piaponon; Primolut; Progekan; Progesterol; Progestin; Progestone; Progestron; Prolets; Prolidon; Proluton; Protormone; synGestrets; synTolutan; 4-Pregnen-3,20-dione; δ-Pregnene-3,20-dione; β-Progesterone; δ4-Pregnene-3,20-dione; Colprosterone; Cyclogest; Lingusorbs; Lucorteum; Membrettes; Methylpregnone; NSC-9704; Pregn-4-ene-3,20-dione, 17α-hydroxy-6α-methyl-; Pregnene-3,20-dione; Pregnenedione; Progestasert; Progesteronum; Progestosol; Progestronol; Prolutin; Syngesterone; Synovex S; Utrogestan; 17α-Progesterone; 4-Pregnene-3,20-dione; Gesterol 100; Percutacrine; Prolutone; Gesterol 50; Gestiron; Lutocuclin M; Pregn-4-en-3,20-dione; Progestogel; Progestol; Progeston; Pregnene, 3,20-dione-delta^4-; Utrogest; Vitarrine; Crinone; Estima; Lugesteron; Luteum; Progeffik; Pregnene, 3,20-dione-delta4-; Cyclogesterin (Salt/Mix)
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Condensed phase thermochemistry data
Go To: Top, Phase change data, IR Spectrum, Mass spectrum (electron ionization), References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein
| Quantity | Value | Units | Method | Reference | Comment |
|---|---|---|---|---|---|
| ΔcH°solid | -2868. ± 5. | kcal/mol | Ccb | Paoli, Garrigues, et al., 1969 | Corresponding ΔfHºsolid = -132. kcal/mol (simple calculation by NIST; no Washburn corrections) |
Phase change data
Go To: Top, Condensed phase thermochemistry data, IR Spectrum, Mass spectrum (electron ionization), References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos
| Quantity | Value | Units | Method | Reference | Comment |
|---|---|---|---|---|---|
| Tfus | 403. | K | N/A | Grady, Hays, et al., 1973 | Uncertainty assigned by TRC = 1. K; TRC |
Enthalpy of fusion
| ΔfusH (kcal/mol) | Temperature (K) | Reference | Comment |
|---|---|---|---|
| 6.451 | 404. | Regosz, Chmielewska, et al., 1994 | AC |
IR Spectrum
Go To: Top, Condensed phase thermochemistry data, Phase change data, Mass spectrum (electron ionization), References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: Coblentz Society, Inc.
Condensed Phase Spectrum
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Notice: Except where noted, spectra from this collection were measured on dispersive instruments, often in carefully selected solvents, and hence may differ in detail from measurements on FTIR instruments or in other chemical environments. More information on the manner in which spectra in this collection were collected can be found here.
Notice: Concentration information is not available for this spectrum and, therefore, molar absorptivity values cannot be derived.
Additional Data
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| Owner | COBLENTZ SOC. Collection (C) 2018 copyright by the U.S. Secretary of Commerce on behalf of the United States of America. All rights reserved. |
|---|---|
| Source reference | COBLENTZ NO. 05045 |
| Date | 1963/06/19 |
| Name(s) | pregn-4-ene-3,20-dione PROGESTERONE |
| State | SOLUTION 1% (CS2 FOR 2-6.2 AND 7.2-15 microns, AND C2Cl4 FOR 6.2-7.2 microns) |
| Instrument | PERKIN-ELMER 21 (GRATING) |
| Instrument parameters | FILTER AT ABOUT 10 MICRONS |
| Path length | 0.1 CM |
| Resolution | 2 |
| Sampling procedure | TRANSMISSION |
| Data processing | DIGITIZED BY COBLENTZ SOCIETY (BATCH I) FROM HARD COPY |
| Melting point | 121-131 C |
Mass spectrum (electron ionization)
Go To: Top, Condensed phase thermochemistry data, Phase change data, IR Spectrum, References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
Spectrum
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Additional Data
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Due to licensing restrictions, this spectrum cannot be downloaded.
| Owner | NIST Mass Spectrometry Data Center Collection (C) 2014 copyright by the U.S. Secretary of Commerce on behalf of the United States of America. All rights reserved. |
|---|---|
| Origin | D.HENNEBERG, MAX-PLANCK INSTITUTE, MULHEIM, WEST GERMANY |
| NIST MS number | 62036 |
References
Go To: Top, Condensed phase thermochemistry data, Phase change data, IR Spectrum, Mass spectrum (electron ionization), Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Paoli, Garrigues, et al., 1969
Paoli, D.; Garrigues, J.-C.; Patin, H.,
Combustion microcalorimetry: application to steroids,
C. R. Acad. Sci. Paris, 1969, 268, 780-783. [all data]
Grady, Hays, et al., 1973
Grady, L.T.; Hays, S.E.; King, R.H.; Klein, H.R.; Mader, W.J.; Wyatt, D.K.; Zimmere, R.O.,
Drug purity profiles,
J. Pharm. Sci., 1973, 62, 459. [all data]
Regosz, Chmielewska, et al., 1994
Regosz, A.; Chmielewska, A.; Pelplinska, T.; Kowalski, P.,
Prediction of the solubility of steroid hormones,
Pharmazie, 1994, 49, 5, 371. [all data]
Notes
Go To: Top, Condensed phase thermochemistry data, Phase change data, IR Spectrum, Mass spectrum (electron ionization), References
- Symbols used in this document:
Tfus Fusion (melting) point ΔcH°solid Enthalpy of combustion of solid at standard conditions ΔfusH Enthalpy of fusion - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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