Probenecid
- Formula: C13H19NO4S
- Molecular weight: 285.359
- IUPAC Standard InChI: InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
- IUPAC Standard InChIKey: DBABZHXKTCFAPX-UHFFFAOYSA-N
- CAS Registry Number: 57-66-9
- Chemical structure:
This structure is also available as a 2d Mol file or as a computed 3d SD file
The 3d structure may be viewed using Java or Javascript. - Other names: Benzoic acid, 4-[(dipropylamino)sulfonyl]-; Benzoic acid, p-(dipropylsulfamoyl)-; p-(Dipropylsulfamoyl)benzoic acid; p-(Dipropylsulfamyl)benzoic acid; Apurina; Benecid; Benemid; Benuryl; Ethamide; Probecid; Proben; Probenecid acid; Prolongine; Synergid R; Tubophan; Uricosid; 4-(Dipropylsulfamoyl)benzoic acid; NCI-C56097; Probenemid; Probexin; 4-((Dipropylamino)sulfonyl)benzoic acid; NSC 18786; 4-[(Dipropylamino)sulfonyl]benzoic acid (probenecid)
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Phase change data
Go To: Top, Gas Chromatography, References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: William E. Acree, Jr., James S. Chickos
Enthalpy of fusion
| ΔfusH (kcal/mol) | Temperature (K) | Method | Reference |
|---|---|---|---|
| 8.023 | 471. | DSC | Peña, Escalera, et al., 2009 |
| 9.78 | 472.1 | DSC | Wassvik, Holmén, et al., 2006 |
Gas Chromatography
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
Normal alkane RI, non-polar column, custom temperature program
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Capillary | Polydimethyl siloxanes | 2336. | Schutz and Wollrab A., 1988 | Program: not specified |
| Other | Methyl Silicone | 2336. | Ardrey and Moffat, 1981 | Program: not specified |
References
Go To: Top, Phase change data, Gas Chromatography, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Peña, Escalera, et al., 2009
Peña, M.A.; Escalera, B.; Reíllo, A.; Sánchez, A.B.; Bustamante, P.,
Thermodynamics of cosolvent action: Phenacetin, salicylic acid and probenecid,
J. Pharm. Sci., 2009, 98, 3, 1129-1135, https://doi.org/10.1002/jps.21497
. [all data]
Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per,
Contribution of solid-state properties to the aqueous solubility of drugs,
European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013
. [all data]
Schutz and Wollrab A., 1988
Schutz, H.; Wollrab A.,
The significance of the retention index in toxicologic analysis II,
Pharmazie in unzerer Zeit, 1988, 17, 4, 97-101. [all data]
Ardrey and Moffat, 1981
Ardrey, R.E.; Moffat, A.C.,
Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase,
J. Chromatogr., 1981, 220, 3, 195-252, https://doi.org/10.1016/S0021-9673(00)81925-1
. [all data]
Notes
Go To: Top, Phase change data, Gas Chromatography, References
- Symbols used in this document:
ΔfusH Enthalpy of fusion - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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