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Aspirin

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Normal melting point

Go To: Top, References, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny, director

Tfus (K) Reference Comment
409.El-Banna, 1978Uncertainty assigned by TRC = 3. K; TRC
414.Schwartzman, 1972Uncertainty assigned by TRC = 4. K; TRC
405.Schwartzman, 1972Uncertainty assigned by TRC = 12. K; deterimined with hot-stage microsope. Concludes that aspirin does not exist in polymorphic forms; TRC
412.Schwartzman, 1972Uncertainty assigned by TRC = 5. K; by "differential thermal absorption". Concludes that aspirin does not exist in polymorphic forms; TRC
403.Schwartzman, 1972Uncertainty assigned by TRC = 8. K; Determined with hot stage microscope. Concludes that aspirin does not exist in polymorphic forms; TRC
415.Schwartzman, 1972Uncertainty assigned by TRC = 3. K; By "differntial thermal absorption". Concludes that aspirin does not exist in polymorphic forms; TRC
414.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 5. K; by differential thermal analysis; TRC
410.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 6. K; by differential thermal analysis; TRC
410.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 5. K; by differential thermal analysis; TRC
402.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 10. K; by differential thermal analysis; TRC
405.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 10. K; by differential thermal analysis; TRC
388.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 15. K; by differential thermal analysis; TRC
388.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 15. K; by differential thermal analysis, peak also obs. at 127 deg; TRC
387.Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 15. K; by differential thermal analysis, peak also obs. at 130 deg; TRC
409.8Mulley, Rye, et al., 1971Uncertainty assigned by TRC = 4. K; by differential thermal analysis Concludes that various m.p. values due to impurities, not polymorphism; TRC
408.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 5. K; identified as polymorphic for I by DSC; TRC
406.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 5. K; identified as polymorphic for I by DSC; TRC
402.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; identified as polymorphic form II by hot stage microscope; TRC
401.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; identified as polymorphic form II by DSC; TRC
396.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 8. K; identified as polymorphic form II by DSC; TRC
387.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 8. K; identified as polymorphic form III by DSC; TRC
397.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 8. K; identified as polymorphic form II by hot stage microscope; TRC
388.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 8. K; idnetified as polymorphic form III by hot stage microscope; TRC
396.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; identified as polymorphic form IV by DSC; TRC
394.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; identified as polymorphic form IV by hot stage microscope; TRC
392.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; indentified as polymorphic form IV by DSC; TRC
373.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; identified as form V by DSC; TRC; Data excluded from overall average
391.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; indetified as polymorphic form IV by hot stage microscope; TRC
373.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 6. K; identified as form V by hot stage microscope; TRC; Data excluded from overall average
381.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 10. K; identifed as polymorphic form VI 1 by DSC; TRC; Data excluded from overall average
383.Summers, Carless, et al., 1970Uncertainty assigned by TRC = 10. K; identifed as polymorphic form VI by hot stage microscope; TRC; Data excluded from overall average
416.Wheatley, 1964Uncertainty assigned by TRC = 3. K; TRC
400.Zaremba, 1962Crystal phase 1 phase; Uncertainty assigned by TRC = 2. K; TRC
395.Zaremba, 1962Crystal phase 2 phase; Uncertainty assigned by TRC = 2. K; TRC
391.Zaremba, 1962Crystal phase 3 phase; Uncertainty assigned by TRC = 2. K; TRC
408.Komandin and Bonetskaya, 1960Uncertainty assigned by TRC = 5. K; TRC
416.Kofler and Sitte, 1950Uncertainty assigned by TRC = 3. K; with "hot stage"; TRC
406.Kofler and Sitte, 1950Uncertainty assigned by TRC = 10. K; under a microscope; TRC
404.9Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X method, not ground; TRC
404.5Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X. method, ground; TRC
407.1Carswell, 1927Uncertainty assigned by TRC = 2.5 K; by Dahm method, not ground; TRC
406.4Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm method, ground; TRC
407.8Carswell, 1927Uncertainty assigned by TRC = 2. K; by German Pharm. method not ground; TRC
407.0Carswell, 1927Uncertainty assigned by TRC = 2.5 K; by German Pharm. method, ground; TRC
404.5Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X method, not ground; TRC
404.3Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X method, ground; TRC
405.8Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm method, not ground; TRC
405.3Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm method, ground; TRC
409.0Carswell, 1927Uncertainty assigned by TRC = 2.5 K; by German Pharm. method, not ground; TRC
407.3Carswell, 1927Uncertainty assigned by TRC = 2. K; by German Pharm. method, ground; TRC
405.25Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X method, not ground; TRC
403.5Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X method, ground; TRC
406.8Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm method, not ground; TRC
405.9Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm method, ground; TRC
409.3Carswell, 1927Uncertainty assigned by TRC = 2. K; by German Pharm. method, not ground; TRC
407.1Carswell, 1927Uncertainty assigned by TRC = 2. K; by German Pharm. method, ground; TRC
404.7Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X method, not ground; TRC
404.8Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X. method, ground; TRC
406.5Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm metho, not ground; TRC
407.9Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm method, ground; TRC
407.5Carswell, 1927Uncertainty assigned by TRC = 2.5 K; by German Pharm. method, not ground; TRC
407.5Carswell, 1927Uncertainty assigned by TRC = 2. K; by German Pharm. method, ground; TRC
404.1Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X method, not ground; TRC
404.3Carswell, 1927Uncertainty assigned by TRC = 2. K; by U.S.P.X. method, ground; TRC
407.2Carswell, 1927Uncertainty assigned by TRC = 2.5 K; by Dahm metho, not ground; TRC
406.7Carswell, 1927Uncertainty assigned by TRC = 2. K; by Dahm method, ground; TRC
406.3Carswell, 1927Uncertainty assigned by TRC = 2. K; by German Pharm. method, not ground; TRC
407.6Carswell, 1927Uncertainty assigned by TRC = 2. K; by German Pharm. method, ground; TRC
407.2Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
402.2Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 4. K; TRC
406.7Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
406.2Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
407.2Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
407.2Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
407.7Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
408.0Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
406.2Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
409.0Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
408.2Hayman, Wagener, et al., 1925Uncertainty assigned by TRC = 2. K; TRC
406.8Putnam, 1924Uncertainty assigned by TRC = 0.5 K; Dahms melting point apparatus, Hg-in-glass thermometer, graduated 0.1 deg, calibr. Reichsanstalt thermometer; TRC
406.8Putnam, 1924Uncertainty assigned by TRC = 0.5 K; Dahm melting point apparatus, Hg-in-glass thermometer, graduated 0.1 deg, calibr. Reichsanstalt thermometer; TRC
406.6Putnam, 1924Uncertainty assigned by TRC = 0.5 K; in Dahm melting point apparatus, Hg-in-glass thermometer, graduated 0.1 deg., calibr. Reighsanstalt thermodmeter; TRC
407.8Ahrens, 1920Uncertainty assigned by TRC = 2. K; TRC
402.1Ahrens, 1920Uncertainty assigned by TRC = 4. K; TRC
402.5Ahrens, 1920Uncertainty assigned by TRC = 4. K; TRC
405.9Ahrens, 1920Uncertainty assigned by TRC = 3. K; TRC
406.9Ahrens, 1920Uncertainty assigned by TRC = 3. K; TRC
407.Auerbach, 1920Uncertainty assigned by TRC = 3. K; TRC
408.Capelli, 1920Uncertainty assigned by TRC = 1.5 K; Best value for dried samples in capillary tube. review of literature shows rage of 124 to 130, depending on crystalizing solvent; TRC
407.4Capelli, 1920, 2Uncertainty assigned by TRC = 0.5 K; TRC
407.7Capelli, 1920, 2Uncertainty assigned by TRC = 0.5 K; TRC
134.8Capelli, 1920, 2Uncertainty assigned by TRC = 0.5 K; TRC; Data excluded from overall average
407.Andrews and Herron, 1919Uncertainty assigned by TRC = 3. K; TRC
412.Andrews and Herron, 1919Uncertainty assigned by TRC = 4. K; TRC
407.2Dahm, 1919Uncertainty assigned by TRC = 2. K; TRC
407.2Dahm, 1919Uncertainty assigned by TRC = 2. K; TRC
407.1Dahm, 1919Uncertainty assigned by TRC = 3. K; TRC
407.5Dahm, 1919Uncertainty assigned by TRC = 2. K; TRC
405.4Leech, 1919Uncertainty assigned by TRC = 1. K; pre-heated to 120 deg C; TRC
407.9Leech, 1919Uncertainty assigned by TRC = 2. K; pre-heated to 130 deg C; TRC
405.4Leech, 1919Uncertainty assigned by TRC = 1. K; pre-heated to 120 deg C; TRC
407.9Leech, 1919Uncertainty assigned by TRC = 2. K; pre-heated to 130 deg C; TRC
405.4Leech, 1919Uncertainty assigned by TRC = 1. K; pre-heated to 120 deg C; TRC
407.9Leech, 1919Uncertainty assigned by TRC = 2. K; pre-heated to 130 deg C; TRC
405.2Leech, 1918Uncertainty assigned by TRC = 2. K; TRC
273.15Leech, 1918Uncertainty assigned by TRC = 5. K; melting point of 16 commerical samples ranged froom 128 to 133 deg C; TRC; Data excluded from overall average
405.Francois, 1917Uncertainty assigned by TRC = 3. K; TRC
398.Tsakalotos, 1916Uncertainty assigned by TRC = 6. K; TRC
397.7Nierenstein, 1909Uncertainty assigned by TRC = 3. K; TRC
510.Reychler, 1908Uncertainty assigned by TRC = 4. K; TRC; Data excluded from overall average

In addition to the Thermodynamics Research Center (TRC) data available from this site, much more physical and chemical property data is available from the following TRC products:


References

Go To: Top, Normal melting point, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

El-Banna, 1978
El-Banna, H.M., Solid Dispersion of Pharmaceutaical Ternary Systems I. Phase Diagrams of Aspirin- Acetominophen-Urea Systems, J. Pharm. Sci., 1978, 67, 1109. [all data]

Schwartzman, 1972
Schwartzman, G., Does Aspirin Exist in Polymorphic States, J. Pharm. Pharmacol., 1972, 24, 169. [all data]

Mulley, Rye, et al., 1971
Mulley, B.A.; Rye, R.M.; Shaw, P., Polymorphism in Aspirin, J. Pharm. Pharmacol., 1971, 1971, 23. 902. [all data]

Summers, Carless, et al., 1970
Summers, M.P.; Carless, J.E.; Enever, R.P., Polymorphism in Aspirin, J. Pharm. Pharmacol., 1970, 22, 615. [all data]

Wheatley, 1964
Wheatley, P.J., The Crystal and Molecular Structure of Aspirin, J. Chem. Soc., 1964, 1964, 6036-48. [all data]

Zaremba, 1962
Zaremba, V.G., Study of Appearance of Various Crystalline Modifications in Supercooled Organic Liquids in Crystallization and Phase Transitions, Acad. Sci., BSSR: Minsk, p 113, 1962. [all data]

Komandin and Bonetskaya, 1960
Komandin, A.V.; Bonetskaya, I.K., Dielectric Constants of Some Organic Compounds Over A Wide Temperature Range, Zh. Fiz. Khim., 1960, 34, 845. [all data]

Kofler and Sitte, 1950
Kofler, L.; Sitte, H., Melting Point Determination of Substances with Melt with Decomposition, Monatsh. Chem., 1950, 81, 619. [all data]

Carswell, 1927
Carswell, T.S., The Melting Point of Acetylsalicylic Acid, J. Am. Pharm. Assoc., 1927, 16, 306. [all data]

Hayman, Wagener, et al., 1925
Hayman, J.L.; Wagener, L.R.; Holden, E.F., Some Physical Constants of Acetylsalicylic Acid, J. Am. Pharm. Assoc., 1925, 14, 388. [all data]

Putnam, 1924
Putnam, M.E., Melting Point of Acetylsalicylic Acid, Ind. Eng. Chem., 1924, 16, 778. [all data]

Ahrens, 1920
Ahrens, C., Melting Point of Acetylsalicylic Acid, Pharm. Ztg., 1920, 65, 800. [all data]

Auerbach, 1920
Auerbach, M., Melting Point of Acetylsalicylic Acid, Pharm. Ztg., 1920, 65, 509. [all data]

Capelli, 1920
Capelli, G., Melting Point of Acetylsalicylic Acid, G. Chim. Ind. Appl., 1920, 2, 291. [all data]

Capelli, 1920, 2
Capelli, G., Crystallization of Acetylsalicylic Acid, G. Chim. Ind. Appl., 1920, 2, 379. [all data]

Andrews and Herron, 1919
Andrews, L.T.; Herron, C.S., A Simple Method for Acetylsalicylic Acid Assay, Am. Drug, 1919, 67, 3, 25. [all data]

Dahm, 1919
Dahm, H.L., Some Notes on Acetylsalicylic Acid, Ind. Eng. Chem., 1919, 11, 29. [all data]

Leech, 1919
Leech, P.N., The Melting Point of Acetylsalicylic Acid, Rep. Lab. Am. Med. Assoc., 1919, 12, 62. [all data]

Leech, 1918
Leech, P.N., Examples of American-Made Acetylsalicylic Acid, Ind. Eng. Chem., 1918, 10, 288. [all data]

Francois, 1917
Francois, M., Assay of Aspirin, J. Pharm. Chim., 1917, 15, 213. [all data]

Tsakalotos, 1916
Tsakalotos, D.E., Physical and Chemical Characteristics of Aspirin, J. Pharm. Chim., 1916, 14, 174. [all data]

Nierenstein, 1909
Nierenstein, M., Constitution of Tannins, Chem. Ber., 1909, 40, 916. [all data]

Reychler, 1908
Reychler, A., The Production and Preparation of Esters, Chem. Centr. I, 1908, 1908, 1042. [all data]


Notes

Go To: Top, Normal melting point, References