Aspirin

• Formula: C₉H₈O₄
• Molecular weight: 180.1574
• IUPAC Standard InChI: InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) Copy

  
• IUPAC Standard InChIKey: BSYNRYMUTXBXSQ-UHFFFAOYSA-N Copy
• CAS Registry Number: 50-78-2
• Chemical structure:
  This structure is also available as a 2d Mol file or as a computed 3d SD file
  The 3d structure may be viewed using Java or Javascript.
• Other names: Benzoic acid, 2-(acetyloxy)-; Salicylic acid acetate; o-Acetoxybenzoic acid; o-Carboxyphenyl acetate; A.S.A.; A.S.A. Empirin; Acenterine; Acesal; Acetal; Aceticyl; Acetilum Acidulatum; Acetisal; Acetol; Acetophen; Acetosal; Acetosalic acid; Acetosalin; Acetylin; Acetylsal; Acetylsalicylic acid; Acidum acetylsalicylicum; Acisal; Acylpyrin; Asagran; Aspro; Asteric; AC 5230; ASA; Benaspir; Bialpirina; Colfarit; Dolean PH 8; Duramax; Ecotrin; Empirin; Endydol; Enterophen; Enterosarein; Enterosarine; Globentyl; Globoid; Helicon; Idragin; Measurin; Neuronika; Novid; Polopiryna; Rheumintabletten; Rhodine; Rhonal; Salacetin; Salcetogen; Saletin; SP 189; Temperal; Triple-Sal; Xaxa; Yasta; 2-(Acetyloxy)benzoic acid; 2-Acetoxybenzoic acid; 2-Carboxyphenyl acetate; O-acetylsalicylic acid; Acetonyl; Acetylsalicylsaure; Acide acetylsalicylique; Adiro; Aspec; Aspergum; Aspirdrops; Aspirine; Bi-prin; Cemirit; Claradin; Clariprin; Crystar; Decaten; Ecolen; Entericin; Extren; ECM; Levius; Micristin; Pharmacin; Pirseal; Premaspin; S-211; Solfrin; Solprin acid; Spira-Dine; St. Joseph; Acetilsalicilico; Acido acetilsalicilico; Acimetten; Acido O-acetil-benzoico; Asatard; Aspalon; Bialpirinia; Caprin; Contrheuma retard; Delgesic; Entrophen; Kyselina 2-acetoxybenzoova; Kyselina acetylsalicylova; Solpyron; Bayer; Bufferin; Easprin; St. Joseph Aspirin for Adults; 2-Acetylsalicyclic acid; Ascoden-30; Coricidin; Nu-seals; Nu-seals aspirin; Persistin; Supac; Tasprin; Triaminicin; Salicylic acid, acetyl-; o-(Acetyloxy)benzoic acid; Zorprin; Magnecyl; Miniasal; Colsprin; Acesan; Acetard; Ascolong; Aspropharm; Salycylacetylsalicylic acid; Kapsazal
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• Information on this page:
  • Normal melting point
  • References
  • Notes
• Other data available:
  • Phase change data
  • Reaction thermochemistry data
  • IR Spectrum
  • THz IR spectrum
  • Mass spectrum (electron ionization)
  • UV/Visible spectrum
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Normal melting point

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

El-Banna, 1978
El-Banna, H.M., Solid Dispersion of Pharmaceutaical Ternary Systems I. Phase Diagrams of Aspirin- Acetominophen-Urea Systems, J. Pharm. Sci., 1978, 67, 1109. [all data]

Schwartzman, 1972
Schwartzman, G., Does Aspirin Exist in Polymorphic States, J. Pharm. Pharmacol., 1972, 24, 169. [all data]

Mulley, Rye, et al., 1971
Mulley, B.A.; Rye, R.M.; Shaw, P., Polymorphism in Aspirin, J. Pharm. Pharmacol., 1971, 1971, 23. 902. [all data]

Summers, Carless, et al., 1970
Summers, M.P.; Carless, J.E.; Enever, R.P., Polymorphism in Aspirin, J. Pharm. Pharmacol., 1970, 22, 615. [all data]

Wheatley, 1964
Wheatley, P.J., The Crystal and Molecular Structure of Aspirin, J. Chem. Soc., 1964, 1964, 6036-48. [all data]

Zaremba, 1962
Zaremba, V.G., Study of Appearance of Various Crystalline Modifications in Supercooled Organic Liquids in Crystallization and Phase Transitions, Acad. Sci., BSSR: Minsk, p 113, 1962. [all data]

Komandin and Bonetskaya, 1960
Komandin, A.V.; Bonetskaya, I.K., Dielectric Constants of Some Organic Compounds Over A Wide Temperature Range, Zh. Fiz. Khim., 1960, 34, 845. [all data]

Kofler and Sitte, 1950
Kofler, L.; Sitte, H., Melting Point Determination of Substances with Melt with Decomposition, Monatsh. Chem., 1950, 81, 619. [all data]

Carswell, 1927
Carswell, T.S., The Melting Point of Acetylsalicylic Acid, J. Am. Pharm. Assoc., 1927, 16, 306. [all data]

Hayman, Wagener, et al., 1925
Hayman, J.L.; Wagener, L.R.; Holden, E.F., Some Physical Constants of Acetylsalicylic Acid, J. Am. Pharm. Assoc., 1925, 14, 388. [all data]

Putnam, 1924
Putnam, M.E., Melting Point of Acetylsalicylic Acid, Ind. Eng. Chem., 1924, 16, 778. [all data]

Ahrens, 1920
Ahrens, C., Melting Point of Acetylsalicylic Acid, Pharm. Ztg., 1920, 65, 800. [all data]

Auerbach, 1920
Auerbach, M., Melting Point of Acetylsalicylic Acid, Pharm. Ztg., 1920, 65, 509. [all data]

Capelli, 1920
Capelli, G., Melting Point of Acetylsalicylic Acid, G. Chim. Ind. Appl., 1920, 2, 291. [all data]

Capelli, 1920, 2
Capelli, G., Crystallization of Acetylsalicylic Acid, G. Chim. Ind. Appl., 1920, 2, 379. [all data]

Andrews and Herron, 1919
Andrews, L.T.; Herron, C.S., A Simple Method for Acetylsalicylic Acid Assay, Am. Drug, 1919, 67, 3, 25. [all data]

Dahm, 1919
Dahm, H.L., Some Notes on Acetylsalicylic Acid, Ind. Eng. Chem., 1919, 11, 29. [all data]

Leech, 1919
Leech, P.N., The Melting Point of Acetylsalicylic Acid, Rep. Lab. Am. Med. Assoc., 1919, 12, 62. [all data]

Leech, 1918
Leech, P.N., Examples of American-Made Acetylsalicylic Acid, Ind. Eng. Chem., 1918, 10, 288. [all data]

Francois, 1917
Francois, M., Assay of Aspirin, J. Pharm. Chim., 1917, 15, 213. [all data]

Tsakalotos, 1916
Tsakalotos, D.E., Physical and Chemical Characteristics of Aspirin, J. Pharm. Chim., 1916, 14, 174. [all data]

Nierenstein, 1909
Nierenstein, M., Constitution of Tannins, Chem. Ber., 1909, 40, 916. [all data]

Reychler, 1908
Reychler, A., The Production and Preparation of Esters, Chem. Centr. I, 1908, 1908, 1042. [all data]

Notes

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• Symbols used in this document:
  

  Tfus	Fusion (melting) point

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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