Niclosamide
- Formula: C13H8Cl2N2O4
- Molecular weight: 327.120
- IUPAC Standard InChI: InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
- IUPAC Standard InChIKey: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
- CAS Registry Number: 50-65-7
- Chemical structure:
This structure is also available as a 2d Mol file - Other names: Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; Salicylanilide, 2',5-dichloro-4'-nitro-; Bayer 2353; Bayluscid; BAY 2353; Cestocid; Devermin; Devermine; Fedal-Telmin; Fenasal; Helmiantin; HL 2447; Iomesan; Lintex; Mansonil; Mato; Nasemo; Phenasal; Radeverm; Sagimid; Sulqui; Tredemine; Vermitid; Vermitin; Yomesan; 2',5-Dichloro-4'-Nitrosalicylanilide; Atenase; Bayer 73; Dichlosale; Iomezan; N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylamide; N-(2'-Chloro-4'-nitrophenyl)-5-chlorosalicylamide; 2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid; 2-Hydroxy-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide; 2',5-Dichlor-4'-nitro-salizylsaeureanilid; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; Chemagro 2353; N-(2'-Chlor-4'-nitrophenyl)-5-chlorsalicylamid; ENT 25823; Niclocide; Cestocide; Ruby; 5-Chloro-N-(2'-chloro-4'-nitrophenyl)salicylamide; WR 46234; Zestocarp; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (niclosamide)
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Phase change data
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: William E. Acree, Jr., James S. Chickos
Enthalpy of fusion
| ΔfusH (kJ/mol) | Temperature (K) | Method | Reference |
|---|---|---|---|
| 40.7 | 505.4 | N/A | Yang and de Villiers, 2005 |
| 35.98 | 502.2 | DSC | van Tonder, Maleka, et al., 2004 |
References
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Yang and de Villiers, 2005
Yang, Wenzhan; de Villiers, Melgardt M.,
Effect of 4-sulphonato-calix[n]arenes and cyclodextrins on the solubilization of niclosamide, a poorly water soluble anthelmintic,
AAPS J, 2005, 7, 1, E241-E248, https://doi.org/10.1208/aapsj070123
. [all data]
van Tonder, Maleka, et al., 2004
van Tonder, Elsa C.; Maleka, Tshoane S.P.; Liebenberg, Wilna; Song, Mingna; Wurster, Dale Eric; de Villiers, Melgardt M.,
Preparation and physicochemical properties of niclosamide anhydrate and two monohydrates,
International Journal of Pharmaceutics, 2004, 269, 2, 417-432, https://doi.org/10.1016/j.ijpharm.2003.09.035
. [all data]
Notes
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- Symbols used in this document:
ΔfusH Enthalpy of fusion - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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