Niflumic acid

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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos

Quantity Value Units Method Reference Comment
Tfus476.0KN/APinvidic, Gonthier-Vassal, et al., 1989Uncertainty assigned by TRC = 0.1 K; TRC
Quantity Value Units Method Reference Comment
Δvap107.5kJ/molS-FPerlovich, Surov, et al., 2007AC
Quantity Value Units Method Reference Comment
Δsub130.2 ± 0.8kJ/molGSPerlovich, Surov, et al., 2007Based on data from 355. to 396. K. See also Surov, Terekhova, et al., 2009.; AC

Enthalpy of sublimation

ΔsubH (kJ/mol) Temperature (K) Method Reference Comment
127.8 ± 0.8376.GSPerlovich, Surov, et al., 2007Based on data from 355. to 396. K. See also Surov, Terekhova, et al., 2009.; AC

Enthalpy of fusion

ΔfusH (kJ/mol) Temperature (K) Method Reference Comment
36.5478.DSCPerlovich, Surov, et al., 2007See also Surov, Terekhova, et al., 2009.; AC
35.7476.4DSCRomero, Bustamante, et al., 2004AC
32.73477.2N/ABustamante, Peña, et al., 1998AC
38.0476.N/APinvidic, Gonthier-Vassal, et al., 1989AC

In addition to the Thermodynamics Research Center (TRC) data available from this site, much more physical and chemical property data is available from the following TRC products:


Gas Chromatography

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Kovats' RI, non-polar column, isothermal

View large format table.

Column type Active phase Temperature (C) I Reference Comment
CapillarySPB-1250.2093.Lora-Tamayo, Rams, et al., 1986He; Column length: 25. m; Column diameter: 0.20 mm

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Pinvidic, Gonthier-Vassal, et al., 1989
Pinvidic, J.J.; Gonthier-Vassal, A.; Szwarc, H.; Ceolin, R.; Toffoli, P.; Teulon, J.M.; Guechot, C., Niflumic acid-morniflumate phase diagram: 1. Study of the components, Thermochim. Acta, 1989, 153, 37-45. [all data]

Perlovich, Surov, et al., 2007
Perlovich, German L.; Surov, Artem O.; Bauer-Brandl, Annette, Thermodynamic properties of flufenamic and niflumic acids---Specific and non-specific interactions in solution and in crystal lattices, mechanism of solvation, partitioning and distribution, Journal of Pharmaceutical and Biomedical Analysis, 2007, 45, 4, 679-687, https://doi.org/10.1016/j.jpba.2007.01.039 . [all data]

Surov, Terekhova, et al., 2009
Surov, Artem O.; Terekhova, Irina V.; Bauer-Brandl, Annette; Perlovich, German L., Thermodynamic and Structural Aspects of Some Fenamate Molecular Crystals, Crystal Growth & Design, 2009, 9, 7, 3265-3272, https://doi.org/10.1021/cg900002q . [all data]

Romero, Bustamante, et al., 2004
Romero, S.; Bustamante, P.; Escalera, B.; Cirri, M.; Mura, P., Characterization of the solid phases of paracetamol and fenamates at equilibrium in saturated solutions, Journal of Thermal Analysis and Calorimetry, 2004, 77, 2, 541-554, https://doi.org/10.1023/B:JTAN.0000038993.61782.ba . [all data]

Bustamante, Peña, et al., 1998
Bustamante, P.; Peña, M.A.; Barra, J., Partial solubility parameters of piroxicam and niflumic acid, International Journal of Pharmaceutics, 1998, 174, 1-2, 141-150, https://doi.org/10.1016/S0378-5173(98)00263-4 . [all data]

Lora-Tamayo, Rams, et al., 1986
Lora-Tamayo, C.; Rams, M.A.; Chacon, J.M.R., Gas Chromatographic Data for 187 Nitrogen- or Phosphorus-Containing Drugs and Metabolites of Toxicological Interest Analysed on Methyl Silicone Capillary Columns, J. Chromatogr., 1986, 374, 73-85, https://doi.org/10.1016/S0378-4347(00)83254-5 . [all data]


Notes

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