3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-

Formula: C₁₆H₁₄ClN₃
Molecular weight: 283.755
IUPAC Standard InChI: InChI=1S/C16H14ClN3/c1-18-15-10-19-16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)20-15/h2-9H,10H2,1H3,(H,18,20)
IUPAC Standard InChIKey: FAMNQSVPYUAUAF-UHFFFAOYSA-N
CAS Registry Number: 4393-72-0
Chemical structure:
This structure is also available as a 2d Mol file
Other names: Chlordiazepam; Desoxychlordiazepoxide; RCDZ; 3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-; Chlordiazepoxide M (desoxo); Chlorodiazepoxide M (desoxo)
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Gas Chromatography

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Column type	Active phase	Temperature (C)	I	Reference	Comment
Capillary	SPB-1	250.	2520.	Lora-Tamayo, Rams, et al., 1986	He; Column length: 25. m; Column diameter: 0.20 mm
Packed	SE-30	250.	2570.	Schütz, 1982	N2
Packed	SE-30	250.	2570.	Schuetz and Westenberger, 1979	N2, Chromosorb G AW DMCS (80-100 mesh); Column length: 1.5 m
Packed	OV-1	250.	2520.	Berninger and Möller, 1977

Column type	Active phase	I	Reference	Comment
Capillary	SPB-1	2516.	Christ, Noomano, et al., 1988	30. m/0.75 mm/1.0 μm, He, 10. K/min, 280. C @ 12. min; T_start: 160. C
Packed	SE-30	2500.	Perrigo and Peel, 1981	N2, Chromosorb W, 130. C @ 2. min, 8. K/min, 290. C @ 8. min; Column length: 1.8 m

Column type	Active phase	I	Reference	Comment
Packed	SE-30	2570.	Marozzi, Gambaro, et al., 1982	Gas Chrom P, 5. K/min; Column length: 2. m; T_start: 150. C; T_end: 300. C

Go To: Top, Gas Chromatography, Notes

Lora-Tamayo, Rams, et al., 1986
Lora-Tamayo, C.; Rams, M.A.; Chacon, J.M.R., Gas Chromatographic Data for 187 Nitrogen- or Phosphorus-Containing Drugs and Metabolites of Toxicological Interest Analysed on Methyl Silicone Capillary Columns, J. Chromatogr., 1986, 374, 73-85, https://doi.org/10.1016/S0378-4347(00)83254-5 . [all data]

Schütz, 1982
Schütz, H., Benzodiazepines, Springer-Verlag, New York, 1982, 438. [all data]

Schuetz and Westenberger, 1979
Schuetz, H.; Westenberger, V., Gas chromatographic data of 31 benzodiazepines and metabolites, J. Chromatogr., 1979, 169, 409-411, https://doi.org/10.1016/0021-9673(75)85071-0 . [all data]

Berninger and Möller, 1977
Berninger, H.; Möller, M.R., Retentionsindices zur gaschromatographischen Identifizierung von Arzneimitteln, Arch. Toxicol., 1977, 37, 4, 295-305, https://doi.org/10.1007/BF00330821 . [all data]

Christ, Noomano, et al., 1988
Christ, D.W.; Noomano, P.; Rosas, M.; Rhone, D., Retention indices by wide-bore capillary gas chromatography with nitrogen-phosphorus detection, J. Anal. Toxicol., 1988, 12, 2, 84-88, https://doi.org/10.1093/jat/12.2.84 . [all data]

Perrigo and Peel, 1981
Perrigo, B.J.; Peel, H.W., The use of retention indices and temperature-programmed gas chromatography in analytical toxicology, J. Chromatogr. Sci., 1981, 19, 5, 219-226, https://doi.org/10.1093/chromsci/19.5.219 . [all data]

Marozzi, Gambaro, et al., 1982
Marozzi, E.; Gambaro, V.; Saligari, E.; Mariani, R.; Lodi, F., Use of the retention index in gas chromatographic studies of drugs, J. Anal. Toxicol., 1982, 6, 4, 185-192, https://doi.org/10.1093/jat/6.4.185 . [all data]

Go To: Top, Gas Chromatography, References

Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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