Fenbufen
- Formula: C16H14O3
- Molecular weight: 254.2806
- IUPAC Standard InChI: InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)
- IUPAC Standard InChIKey: ZPAKPRAICRBAOD-UHFFFAOYSA-N
- CAS Registry Number: 36330-85-5
- Chemical structure:
This structure is also available as a 2d Mol file - Other names: [1,1'-Biphenyl]-4-butanoic acid, γ-oxo-; 3-(4-Biphenylylcarbonyl)propionic acid; 4-(4-Biphenylyl)-4-oxobutyric acid; Bufemid; Butyric acid 4-(4-biphenyl)-4-oxo-; Cinopal; Cinopol; CL 82204; Diphenyl-4-γ-oxo-γ-butyric acid; Lederfen; γ-Oxo(1,1'-biphenyl)-4-butanoic acid; β,p-Phenylbenzoylpropionic acid; 3-(4-Biphenylcarbonyl)propionic acid; 3-(4-Phenylbenzoyl)propionic acid; Napanol; Propionic acid, 3-(4-biphenylylcarbonyl)-; 3-(4-Biphenylylcarbonyl)propionic acid (fenbufen)
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Phase change data
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: William E. Acree, Jr., James S. Chickos
| Quantity | Value | Units | Method | Reference | Comment |
|---|---|---|---|---|---|
| ΔsubH° | 37.0 ± 0.2 | kcal/mol | GS | Kurkov and Perlovich, 2008 | Based on data from 378. to 420. K. |
Enthalpy of fusion
| ΔfusH (kcal/mol) | Temperature (K) | Method | Reference |
|---|---|---|---|
| 9.82 | 462.9 | DSC | Kurkov and Perlovich, 2008 |
| 11.0 | 459.3 | DSC | Wassvik, Holmén, et al., 2006 |
References
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Kurkov and Perlovich, 2008
Kurkov, Sergey V.; Perlovich, German L.,
Thermodynamic studies of Fenbufen, Diflunisal, and Flurbiprofen: Sublimation, solution and solvation of biphenyl substituted drugs,
International Journal of Pharmaceutics, 2008, 357, 1-2, 100-107, https://doi.org/10.1016/j.ijpharm.2008.01.059
. [all data]
Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per,
Contribution of solid-state properties to the aqueous solubility of drugs,
European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013
. [all data]
Notes
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- Symbols used in this document:
ΔfusH Enthalpy of fusion ΔsubH° Enthalpy of sublimation at standard conditions - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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