Piroxicam

• Formula: C₁₅H₁₃N₃O₄S
• Molecular weight: 331.346
• IUPAC Standard InChI: InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) Copy

  
• IUPAC Standard InChIKey: QYSPLQLAKJAUJT-UHFFFAOYSA-N Copy
• CAS Registry Number: 36322-90-4
• Chemical structure:
  This structure is also available as a 2d Mol file or as a computed 3d SD file
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• Other names: 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; CP 16171; Feldene; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide; 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide1,1-dioxide; Artroxicam; Baxo; Bruxicam; Caliment; Erazon; Flogobene; Geldene; Improntal; Larapam; Pirkam; Piroflex; Reudene; Riacen; Roxicam; Roxiden; Sasulen; Solocalm; Zunden; CHF 1251; NSC 666076; Piroftal; Pyroxycam; 2H-1,2-benzothiazine-3-carboxyamide-4-hydroxy-2-methyl-N-2-pyridinyl-1,1-dioxide (piroxicam)
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• Information on this page:
  • Phase change data
  • References
  • Notes
• Other data available:
  • Mass spectrum (electron ionization)
  • Gas Chromatography
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Drebushchak1, Shakhtshneider, et al., 2006
Drebushchak1, V.A.; Shakhtshneider, T.P.; Apenina, S.A.; Drebushchak, T.N.; Medvedeva, A.S.; Safronova, L.P.; Boldyrev, V.V., Thermoanalytical investigation of drug-excipient interaction, J Therm Anal Calorim, 2006, 84, 3, 643-649, https://doi.org/10.1007/s10973-005-9990-4 . [all data]

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Wassvik, Holmén, et al., 2008
Wassvik, Carola M.; Holmén, Anders G.; Draheim, Rieke; Artursson, Per; Bergström, Christel A.S., Molecular Characteristics for Solid-State Limited Solubility, J. Med. Chem., 2008, 51, 10, 3035-3039, https://doi.org/10.1021/jm701587d . [all data]

Bustamante, Peña, et al., 1998
Bustamante, P.; Peña, M.A.; Barra, J., Partial solubility parameters of piroxicam and niflumic acid, International Journal of Pharmaceutics, 1998, 174, 1-2, 141-150, https://doi.org/10.1016/S0378-5173(98)00263-4 . [all data]

Giordano, Gazzaniga, et al., 1998
Giordano, Ferdinando; Gazzaniga, Andrea; Moyano, Jos«65533» Ramon; Ventura, Paolo; Zanol, Margherita; Peveri, Tiziana; Carima, Lorenza, Crystal forms of piroxicam pivalate: Preparation and characterization of two polymorphs, J. Pharm. Sci., 1998, 87, 3, 333-337, https://doi.org/10.1021/js970256b . [all data]

Notes

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• Symbols used in this document:
  

  ΔfusH

  Enthalpy of fusion

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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