Isoflurane
- Formula: C3H2ClF5O
- Molecular weight: 184.492
- IUPAC Standard InChI: InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
- IUPAC Standard InChIKey: PIWKPBJCKXDKJR-UHFFFAOYSA-N
- CAS Registry Number: 26675-46-7
- Chemical structure:
This structure is also available as a 2d Mol file or as a computed 3d SD file
The 3d structure may be viewed using Java or Javascript. - Other names: Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-; Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl; Forane; 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether; Aerrane; 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; Compd 469; Compound 469; Forene; Ethane, 1-chloro-1-(difluoromethoxy)-2,2,2-trifluoro-; IsoFlo; R-E 235dal
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Phase change data
Go To: Top, Gas Chromatography, References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled as indicated in comments:
BS - Robert L. Brown and Stephen E. Stein
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director
AC - William E. Acree, Jr., James S. Chickos
| Quantity | Value | Units | Method | Reference | Comment |
|---|---|---|---|---|---|
| Tboil | 321.6 | K | N/A | PCR Inc., 1990 | BS |
| Quantity | Value | Units | Method | Reference | Comment |
| Tc | 467.8 | K | N/A | Ambrose and Ghiassee, 1988 | Uncertainty assigned by TRC = 0.02 K; Visual, PRT, IPTS-68, PB.; TRC |
| Quantity | Value | Units | Method | Reference | Comment |
| Pc | 30.06 | atm | N/A | Ambrose and Ghiassee, 1988 | Uncertainty assigned by TRC = 0.05 atm; Visual, PRT, IPTS-68, PB.; TRC |
Enthalpy of vaporization
| ΔvapH (kcal/mol) | Temperature (K) | Method | Reference | Comment |
|---|---|---|---|---|
| 7.58 | 295. | N/A | Ambrose and Ghiassee, 1988, 2 | Based on data from 280. to 344. K.; AC |
| 7.62 | 297. | A | Stephenson and Malanowski, 1987 | Based on data from 283. to 312. K.; AC |
Gas Chromatography
Go To: Top, Phase change data, References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
Normal alkane RI, non-polar column, custom temperature program
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Capillary | SPB-1 | 454. | Flanagan, Streete, et al., 1997 | 60. m/0.53 mm/5. μm, He; Program: 40C(6min) => 5C/min => 80C => 10C/min => 200C |
| Capillary | SPB-1 | 454. | Strete, Ruprah, et al., 1992 | 60. m/0.53 mm/5.0 μm, Helium; Program: 40 0C (6 min) 5 0C/min -> 80 0C 10 0C/min -> 200 0C |
References
Go To: Top, Phase change data, Gas Chromatography, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
PCR Inc., 1990
PCR Inc.,
Research Chemicals Catalog 1990-1991, PCR Inc., Gainesville, FL, 1990, 1. [all data]
Ambrose and Ghiassee, 1988
Ambrose, D.; Ghiassee, N.B.,
Vapor Pressure, Critical Temperatures and Critical Pressures of 2-chloro-1,1,2-trifluoroethyl Difluoromethyl Ether (Enflurane) and of 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether (Isoflurane),
J. Chem. Thermodyn., 1988, 20, 765. [all data]
Ambrose and Ghiassee, 1988, 2
Ambrose, D.; Ghiassee, N.B.,
Vapour pressures, critical temperatures, and critical pressures of 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether (enflurane) and of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (isoflurane),
The Journal of Chemical Thermodynamics, 1988, 20, 6, 765-766, https://doi.org/10.1016/0021-9614(88)90029-8
. [all data]
Stephenson and Malanowski, 1987
Stephenson, Richard M.; Malanowski, Stanislaw,
Handbook of the Thermodynamics of Organic Compounds, 1987, https://doi.org/10.1007/978-94-009-3173-2
. [all data]
Flanagan, Streete, et al., 1997
Flanagan, R.J.; Streete, P.J.; Ramsey, J.D.,
Volatile Substance Abuse, UNODC Technical Series, No 5, United Nations, Office on Drugs and Crime, Vienna International Centre, PO Box 500, A-1400 Vienna, Austria, 1997, 56, retrieved from http://www.odccp.org/pdf/technicalseries1997-01-011.pdf. [all data]
Strete, Ruprah, et al., 1992
Strete, P.J.; Ruprah, M.; Ramsey, J.D.; Flanagan, R.J.,
Detection and identification of volatile substances by headspace capillary gas chromatography to aid the diagnosis of acute poisoning,
Analyst, 1992, 117, 7, 1111-1127, https://doi.org/10.1039/an9921701111
. [all data]
Notes
Go To: Top, Phase change data, Gas Chromatography, References
- Symbols used in this document:
Pc Critical pressure Tboil Boiling point Tc Critical temperature ΔvapH Enthalpy of vaporization - Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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