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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

ΔfusH (kJ/mol) Temperature (K) Method Reference Comment
39.5350.4DSCCilurzo, Alberti, et al., 2010 
27.94347.6DSCHong, Hua, et al., 2010 
26.6346.4DSCWassvik, Holmén, et al., 2006 
26.65348.N/AGracin and Rasmuson, 2002See also Xu, Sun, et al., 2004.
25.7350.9DSCLi, Zell, et al., 1999 


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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Cilurzo, Alberti, et al., 2010
Cilurzo, F.; Alberti, E.; Minghetti, P.; Gennari, C.G.M.; Casiraghi, A.; Montanari, L., Effect of drug chirality on the skin permeability of ibuprofen, International Journal of Pharmaceutics, 2010, 386, 1-2, 71-76, https://doi.org/10.1016/j.ijpharm.2009.10.053 . [all data]

Hong, Hua, et al., 2010
Hong, Jindui; Hua, Dan; Wang, Xia; Wang, Hongtao; Li, Jun, Solid-Liquid-Gas Equilibrium of the Ternaries Ibuprofen + Myristic Acid + CO 2 and Ibuprofen + Tripalmitin + CO 2, J. Chem. Eng. Data, 2010, 55, 1, 297-302, https://doi.org/10.1021/je900342a . [all data]

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Gracin and Rasmuson, 2002
Gracin, Sandra; Rasmuson, Åke C., Solubility of Phenylacetic Acid, p -Hydroxyphenylacetic Acid, p -Aminophenylacetic Acid, p -Hydroxybenzoic Acid, and Ibuprofen in Pure Solvents, J. Chem. Eng. Data, 2002, 47, 6, 1379-1383, https://doi.org/10.1021/je0255170 . [all data]

Xu, Sun, et al., 2004
Xu, Fen; Sun, Li-Xian; Tan, Zhi-Cheng; Liang, Jian-Guo; Li, Rui-Lian, Thermodynamic study of ibuprofen by adiabatic calorimetry and thermal analysis, Thermochimica Acta, 2004, 412, 1-2, 33-57, https://doi.org/10.1016/j.tca.2003.08.021 . [all data]

Li, Zell, et al., 1999
Li, Z. Jane; Zell, Mark T.; Munson, Eric J.; Grant, David J.W., Characterization of racemic species of chiral drugs using thermal analysis, thermodynamic calculation, and structural studies, J. Pharm. Sci., 1999, 88, 3, 337-346, https://doi.org/10.1021/js980205u . [all data]


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