Pindolol

• Formula: C₁₄H₂₀N₂O₂
• Molecular weight: 248.3208
• IUPAC Standard InChI: InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3 Copy

  
• IUPAC Standard InChIKey: JZQKKSLKJUAGIC-UHFFFAOYSA-N Copy
• CAS Registry Number: 13523-86-9
• Chemical structure:
  This structure is also available as a 2d Mol file or as a computed 3d SD file
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• Other names: 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-; Calvisken; 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole; 1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol; 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol; LB-46; Prinodolol; 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-; Visken; 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol; Betapindol; Blockin L; Blocklin L; Decreten; Durapindol; Glauco-Visken; Pectobloc; Pinbetol; Pynastin; (.+/-.)-Pindolol; 4-(3-(Isopropylamino)-2-hydroxypropoxy)indole; Carvisken; (±) 1-(1H-indol-4-yloxy)-3-(isopropylamino)-2-propanol (pindolol)
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• Information on this page:
  • Phase change data
  • Gas Chromatography
  • References
  • Notes
• Other data available:
  • Mass spectrum (electron ionization)
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

Gas Chromatography

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Kovats' RI, non-polar column, isothermal

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Kovats' RI, non-polar column, custom temperature program

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Normal alkane RI, non-polar column, custom temperature program

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References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Perlovich, Volkova, et al., 2007
Perlovich, German L.; Volkova, Tatyana V.; Bauer-Brandl, Annette, Thermodynamic Study of Sublimation, Solubility, Solvation, and Distribution Processes of Atenolol and Pindolol, Mol. Pharmaceutics, 2007, 4, 6, 929-935, https://doi.org/10.1021/mp070039b . [all data]

Nunes, Eusébio, et al., 2004
Nunes, Sandra C.C.; Eusébio, M. Ermelinda; Leitão, M. Luísa P.; Redinha, J.S., Polymorphism of pindolol, 1-(1H-indol-4-yloxyl)-3-isopropylamino-propan-2-ol, International Journal of Pharmaceutics, 2004, 285, 1-2, 13-21, https://doi.org/10.1016/j.ijpharm.2004.07.024 . [all data]

Li, Zell, et al., 1999
Li, Z. Jane; Zell, Mark T.; Munson, Eric J.; Grant, David J.W., Characterization of racemic species of chiral drugs using thermal analysis, thermodynamic calculation, and structural studies, J. Pharm. Sci., 1999, 88, 3, 337-346, https://doi.org/10.1021/js980205u . [all data]

Japp, Gill, et al., 1987
Japp, M.; Gill, R.; Osselton, M.D., Comparison of drug retention indices determined on packed, wide bore capillary and narrow bore capillary columns, J. Forensic Sci., 1987, 32, 6, 1574-1586. [all data]

Musumarra, Scarlata, et al., 1987
Musumarra, G.; Scarlata, G.; Romano, G.; Cappello, G.; Clementi, S.; Giulietti, G., Qualitative organic analysis. Part 2. Identification of drugs by principal components analysis of standardized TLC data in four eluent systems and of retention indices on SE 30, J. Anal. Toxicol., 1987, 11, 4, 154-163, https://doi.org/10.1093/jat/11.4.154 . [all data]

McLinden and Stenhouse, 1979
McLinden, V.J.; Stenhouse, A.M., A chromatography system for drug identification, Forensic Sci. Int., 1979, 13, 71-79, https://doi.org/10.1016/0379-0738(79)90265-2 . [all data]

Ardrey and Moffat, 1981
Ardrey, R.E.; Moffat, A.C., Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase, J. Chromatogr., 1981, 220, 3, 195-252, https://doi.org/10.1016/S0021-9673(00)81925-1 . [all data]

Notes

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• Symbols used in this document:
  

  ΔfusH	Enthalpy of fusion
  ΔsubH°	Enthalpy of sublimation at standard conditions

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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