Androst-5-ene-3β,17β-diol, 2TMS derivative
- Formula: C25H46O2Si2
- Molecular weight: 434.8025
- IUPAC Standard InChI: InChI=1S/C25H46O2Si2/c1-24-15-13-19(26-28(3,4)5)17-18(24)9-10-20-21-11-12-23(27-29(6,7)8)25(21,2)16-14-22(20)24/h9,19-23H,10-17H2,1-8H3/t19-,20?,21?,22?,23-,24?,25?/m1/s1
- IUPAC Standard InChIKey: YXSPGYZGGCSNLG-DUYKKJJHSA-N
- CAS Registry Number: 13110-76-4
- Chemical structure:
This structure is also available as a 2d Mol file - Stereoisomers:
- Other names: 3β,17β-Bis(trimethylsiloxy)androst-5-ene; Silane, [[(3β,17β)-androst-5-ene-3,17-diyl]bis(oxy)]bis[trimethyl-; Silane, (androst-5-en-3β,17β-ylenedioxy)bis[trimethyl-; 3β,17β-Bis(trimethylsilyloxy)androst-5-ene; Trimethylsilyl derivative of 5-Androstene-3β,17β-diol; 3,17-Bis[(trimethylsilyl)oxy]androst-5-ene, (3β,17β)-; 5-Androsten-3-β,17-β-diol, bis-TMS; Androst-5-ene-3β,17β-diol, di-TMS; Androst-5-ene-3B,17B-diol, TMS; 5-Androsten-3-β,17-β-diol, TMS; Androstenediol, di-TMS; Androstenediol, MO TMS
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Gas Chromatography
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
Kovats' RI, non-polar column, isothermal
| Column type | Active phase | Temperature (C) | I | Reference | Comment |
|---|---|---|---|---|---|
| Packed | OV-1 | 235. | 2620. | Smith, Joannou, et al., 1978 | N2, Gas-Chrom Q (100-120 mesh); Column length: 2.5 m |
| Packed | OV-101 | 207. | 2625. | Berthou, Picart, et al., 1976 | Column length: 2.1 m |
| Capillary | OV-101 | 252. | 2648. | Berthou, Picart, et al., 1976 | Column length: 55. m; Column diameter: 0.37 mm |
| Capillary | OV-101 | 252. | 2650. | Berthou, Picart, et al., 1976 | Column length: 55. m; Column diameter: 0.37 mm |
Van Den Dool and Kratz RI, non-polar column, custom temperature program
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Capillary | BP-1 | 2657. | Hähnel, Wilkinson, et al., 1985 | He; Column length: 25. m; Column diameter: 0.3 mm; Program: 40C (1min) => 20C/min => 200C => 2C/min => 300C (11min) |
Normal alkane RI, non-polar column, temperature ramp
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Packed | SE-30 | 2612. | Harvey, 1980 | N2, Gas Chrom Q, 4. K/min; Column length: 2. m; Tstart: 150. C; Tend: 300. C |
| Packed | SE-30 | 2612. | Harvey, 1977 | N2, Gas Chrom Q, 2. K/min; Column length: 2.0 m; Tstart: 150. C; Tend: 290. C |
References
Go To: Top, Gas Chromatography, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Smith, Joannou, et al., 1978
Smith, A.G.; Joannou, G.E.; Mák, M.; Uwajima, T.; Terada, O.; Brooks, C.J.W.,
Oxidation of 3β-hydroxyandrostenes by the 3β-hydroxysteroid oxidase (cholesterol oxidase) from Brevibacterium sterolicum prior to their analysis by gas-liquid chromatography-mass spectrometry,
J. Chromatogr., 1978, 152, 2, 467-474, https://doi.org/10.1016/S0021-9673(00)85083-9
. [all data]
Berthou, Picart, et al., 1976
Berthou, F.; Picart, D.; Bardou, L.; Floch, H.H.,
Separation of C19 and C21 dihydroxysteroids by open-hole tubular glass columns and lipophilic gel chromatography,
J. Chromatogr., 1976, 118, 2, 135-155, https://doi.org/10.1016/S0021-9673(00)81203-0
. [all data]
Hähnel, Wilkinson, et al., 1985
Hähnel, E.; Wilkinson, S.P.; Hähnel, R.,
Urinary steroid profiles in pregnancy by capillary column gas chromatography,
Clin. Chim. Acta, 1985, 151, 3, 259-271, https://doi.org/10.1016/0009-8981(85)90089-0
. [all data]
Harvey, 1980
Harvey, D.J.,
Vinyldimethylsilyl ethers as derivative for the characterization of steroids and cannabinoids by gas chromatography mass spectrometry,
Biomed. Mass Spectrom., 1980, 7, 5, 211-216, https://doi.org/10.1002/bms.1200070507
. [all data]
Harvey, 1977
Harvey, D.J.,
Allyldimethylsilyl ethers as derivatives for the characterization of steroids and cannabinoids by combined gas chromatography and mass spectrometry,
Biomed. Mass Spectrom., 1977, 4, 4, 265-274, https://doi.org/10.1002/bms.1200040414
. [all data]
Notes
Go To: Top, Gas Chromatography, References
- Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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