Acetaminophen
- Formula: C8H9NO2
- Molecular weight: 151.1626
- IUPAC Standard InChI: InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
- IUPAC Standard InChIKey: RZVAJINKPMORJF-UHFFFAOYSA-N
- CAS Registry Number: 103-90-2
- Chemical structure:
This structure is also available as a 2d Mol file or as a computed 3d SD file
The 3d structure may be viewed using Java or Javascript. - Other names: Acetamide, N-(4-hydroxyphenyl)-; Acetanilide, 4'-hydroxy-; p-(Acetylamino)phenol; p-Acetamidophenol; p-Hydroxyacetanilide; p-Hydroxyphenolacetamide; Abensanil; Acamol; Acetagesic; Acetalgin; Acetaminofen; Algotropyl; Alvedon; Amadil; Anaflon; Anelix; Apamid; Apamide; APAP; Ben-u-Ron; Bickie-mol; Calpol; Cetadol; Clixodyne; Dial-a-gesic; Dirox; Dymadon; Eneril; Febrilix; Febro-Gesic; Febrolin; Fendon; Finimal; Hedex; Homoolan; Lestemp; Liquagesic; Lonarid; Lyteca; Lyteca Syrup; Multin; N-(4-Hydroxyphenyl)acetamide; N-Acetyl-p-aminophenol; N-Acetyl-4-aminophenol; Napafen; Naprinol; Nobedon; NAPA; NAPAP; Pacemo; Panadol; Panets; Paracetamol; Paracetamole; Paracetanol; Parmol; Pedric; Phendon; Pyrinazine; Tabalgin; Temlo; Tempanal; Tempra; Tralgon; Tussapap; Tylenol; Valadol; Valgesic; 4-Acetamidophenol; 4-Acetaminophenol; 4-Hydroxyacetanilide; 4'-Hydroxyacetanilide; Accu-Tap; Acetamide, N-(p-hydroxyphenyl)-; Alpiny; Anapap; Anhiba; Apadon; Datril; Dimindol; Dularin; Dypap; Elixodyne; Febridol; Febrinol; G 1; Gelocatil; Injectapap; Janupap; Korum; Nealgyl; Nebs; Neotrend; NCI-C55801; Painex; Paracet; Paracetamol DC; Parapan; Phenol, p-acetamido-; Rivalgyl; Servigesic; St. Joseph Fever Reducer; SK-Apap; Tapar; Alpinyl; Doliprane; Enelfa; Exdol; 4-Hydroxyanilid kyseliny octove; Momentum; Panex; Panofen; Paracetamolo; Paraspen; Banesin; Phenaphen; Captin; Dafalgan; Disprol; Dolprone; Eu-Med; Ortensan; Paldesic; Panaleve; Panasorb; Parelan; Pasolind N; Salzone; 4-(Acetylamino)phenol; 4-(N-Acetylamino)phenol; Acenol; Biocetamol; Citramon P; Claratal; Cyclopam; Daga; Daphalgan; Minoset; N-Acetyl-4-hydroxyaniline; Pacemol; Panodil; Pinex; Pyral; Resfenol; Resprin; Vermidon; p-Acetoaminophen; N-(p-Hydroxyphenyl) acetamide; Actifed Plus (Salt/Mix); Anexsia (Salt/Mix); Aspirin-Free Anacin (Salt/Mix); Bayer Select Allergy-Sinus (Salt/Mix); Bayer Select Head Cold (Salt/Mix); Bayer Select Menstrual Multi-Symptom (Salt/Mix); Bayer Select Sinus Pain Relief (Salt/Mix); Contac Cough & Sore Throat Formula (Salt/Mix); Coricidin (Salt/Mix); Coricidin D (Salt/Mix); Coricidin Sinus (Salt/Mix); DHCplus (Salt/Mix); Darvocet-N (Salt/Mix); Demilets (Salt/Mix); Drixoral Cold & Flu (Salt/Mix); Drixoral Sinus (Salt/Mix); Empracet (Salt/Mix); Endecon (Salt/Mix); Hy-Phen (Salt/Mix); Hycomine Compound (Salt/Mix); Intensin (Salt/Mix); Liquiprin (Salt/Mix); Midol Maximum Strength (Salt/Mix); Midol PM Night Time Formula (Salt/Mix); Midol Regular Strength (Salt/Mix); Midol Teen Formula (Salt/Mix); Naldegesic (Salt/Mix); Ornex Severe Cold Formula (Salt/Mix); Percocet (Salt/Mix); Propacet (Salt/Mix); Quiet World (Salt/Mix); Rhinex D-Lay Tablets (Salt/Mix); Robitussin Night Relief (Salt/Mix); Sine-Aid, Maximum Strength (Salt/Mix); Sine-Off Sinus Medicine Caplets (Salt/Mix); Sinubid (Salt/Mix); St. Joseph Cold Tablets for Children (Salt/Mix); Sudafed Cold and Cough (Salt/Mix); Sudafed Severe Cold Formula (Salt/Mix); Sudafed Sinus (Salt/Mix); Supac (Salt/Mix); Talacen (Salt/Mix); TheraFlu (Salt/Mix); Triaminic Sore Throat Formula (Salt/Mix); Tylenol Allergy Sinus (Salt/Mix); Tylox (Salt/Mix); Vanquish (Salt/Mix); Vicodin (Salt/Mix); Zydone (Salt/Mix); Wygesic (Salt/Mix)
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IR Spectrum
Go To: Top, THz IR spectrum, Gas Chromatography, References, Notes
Data compiled by: Coblentz Society, Inc.
Data compiled by: Timothy J. Johnson, Tanya L. Myers, Yin-Fong Su, Russell G. Tonkyn, Molly Rose K. Kelly-Gorham, and Tyler O. Danby
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
THz IR spectrum
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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: Edwin J. Heilweil and Matthew B. Campbell
Condensed Phase Spectrum
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Additional Data
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| Owner | Collection (C) 2005 copyright by the U.S. Secretary of Commerce on behalf of the United States of America. All rights reserved. |
|---|---|
| State | Solid (powder) |
| Sample description | 8.1 mg + 113.5 mg polyethylene spectrograde powder |
| Sample contents | acetaminophen |
Gas Chromatography
Go To: Top, IR Spectrum, THz IR spectrum, References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
Kovats' RI, non-polar column, isothermal
| Column type | Active phase | Temperature (C) | I | Reference | Comment |
|---|---|---|---|---|---|
| Capillary | DB-5 | 220. | 1697. | Phillips, Logan, et al., 1990 | 15. m/0.25 mm/0.2 μm, He |
| Capillary | BP-1 | 200. | 1632. | Japp, Gill, et al., 1987 | 25. m/0.22 mm/0.25 μm, N2 |
| Capillary | BP-1 | 200. | 1643. | Japp, Gill, et al., 1987 | 25. m/0.53 mm/1. μm, N2 |
| Capillary | SPB-1 | 250. | 1650. | Lora-Tamayo, Rams, et al., 1986 | He; Column length: 25. m; Column diameter: 0.20 mm |
| Packed | OV-101 | 190. | 1664. | Möller, 1976 | N2, Chromosorb W; Column length: 2. m |
| Packed | OV-101 | 230. | 1678. | Möller, 1976 | N2, Chromosorb W; Column length: 2. m |
Van Den Dool and Kratz RI, non-polar column, temperature ramp
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Capillary | SPB-1 | 1668. | Christ, Noomano, et al., 1988 | 30. m/0.75 mm/1.0 μm, He, 10. K/min, 280. C @ 12. min; Tstart: 160. C |
| Capillary | DB-1 | 1631. | Perrigo, Peel, et al., 1985 | 15. m/0.32 mm/0.25 μm, He, 8. K/min, 280. C @ 5. min; Tstart: 120. C |
| Capillary | 5 % Phenyl methyl siloxane | 1694.0 | Newton and Foery, 1984 | 12. m/0.2 mm/0.33 μm, He, 50. C @ 1. min, 20. K/min, 300. C @ 3. min |
| Capillary | DB-1 | 1631. | Perrigo, Ballantyne, et al., 1984 | 15. m/0.25 mm/0.25 μm, He, 8. K/min, 280. C @ 5. min; Tstart: 120. C |
Van Den Dool and Kratz RI, non-polar column, custom temperature program
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Capillary | BP-1 | 1636. | Stowell and Wilson, 1987 | 12. m/0.22 mm/0.25 μm, He; Program: 120C => 8C/min => 270C => 25C/min => 300C |
Normal alkane RI, non-polar column, temperature ramp
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Capillary | BPX5 | 1703. | Boustie, Rapior, et al., 2005 | 25. m/0.20 mm/0.13 μm, He, 50. C @ 2. min, 3. K/min; Tend: 230. C |
| Capillary | BP-1 | 1631. | Stowell and Wilson, 1985 | 12. m/0.22 mm/0.25 μm, He, 8. K/min; Tstart: 120. C; Tend: 280. C |
Normal alkane RI, non-polar column, custom temperature program
| Column type | Active phase | I | Reference | Comment |
|---|---|---|---|---|
| Capillary | BP-1 | 1636. | Stowell and Wilson, 1985 | 12. m/0.22 mm/0.25 μm, He; Program: 120 0X 8 0C/min -> 270 0C 25 0C/min -> 300 0C (5 min) |
| Other | Methyl Silicone | 1687. | Ardrey and Moffat, 1981 | Program: not specified |
References
Go To: Top, IR Spectrum, THz IR spectrum, Gas Chromatography, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Phillips, Logan, et al., 1990
Phillips, A.M.; Logan, B.K.; Stafford, D.T.,
Further applications for capillary gas chromatography in routine quantitative toxicological analyses,
J. Hi. Res. Chromatogr., 1990, 13, 11, 754-758, https://doi.org/10.1002/jhrc.1240131106
. [all data]
Japp, Gill, et al., 1987
Japp, M.; Gill, R.; Osselton, M.D.,
Comparison of drug retention indices determined on packed, wide bore capillary and narrow bore capillary columns,
J. Forensic Sci., 1987, 32, 6, 1574-1586. [all data]
Lora-Tamayo, Rams, et al., 1986
Lora-Tamayo, C.; Rams, M.A.; Chacon, J.M.R.,
Gas Chromatographic Data for 187 Nitrogen- or Phosphorus-Containing Drugs and Metabolites of Toxicological Interest Analysed on Methyl Silicone Capillary Columns,
J. Chromatogr., 1986, 374, 73-85, https://doi.org/10.1016/S0378-4347(00)83254-5
. [all data]
Möller, 1976
Möller, M.R.,
Comparability of retention indices of polar substances at elevated temperatures,
Chromatographia, 1976, 9, 7, 311-314, https://doi.org/10.1007/BF02268832
. [all data]
Christ, Noomano, et al., 1988
Christ, D.W.; Noomano, P.; Rosas, M.; Rhone, D.,
Retention indices by wide-bore capillary gas chromatography with nitrogen-phosphorus detection,
J. Anal. Toxicol., 1988, 12, 2, 84-88, https://doi.org/10.1093/jat/12.2.84
. [all data]
Perrigo, Peel, et al., 1985
Perrigo, B.J.; Peel, H.W.; Ballantyne, D.J.,
Use of Dual-Column Fused-Silica Capillary Gas Chromatography in Combination with Detector Response Factors for Analytical Toxicology.,
J. Chromatogr., 1985, 341, 81-88, https://doi.org/10.1016/S0378-4347(00)84011-6
. [all data]
Newton and Foery, 1984
Newton, B.; Foery, R.F.,
Retention indices and dual capillary gas chromatography for rapid identification of sedative hypnotic drugs in emergency toxicology,
J. Anal. Toxicol., 1984, 8, 3, 129-134, https://doi.org/10.1093/jat/8.3.129
. [all data]
Perrigo, Ballantyne, et al., 1984
Perrigo, B.J.; Ballantyne, D.J.; Peel, H.W.,
Condierations in developing a data base for drugs on a DBI capillary column,
J. Can. Soc. Forensic Sci., 1984, 17, 2, 41-49, https://doi.org/10.1080/00085030.1984.10757360
. [all data]
Stowell and Wilson, 1987
Stowell, A.; Wilson, L.W.,
A simple approach to the interlaboratory transfer of drug retention indices determined by temperature programmed capillary gas chromatography,
J. Forensic Sci., 1987, 32, 5, 1214-1220. [all data]
Boustie, Rapior, et al., 2005
Boustie, J.; Rapior, S.; Fortin, H.; Tomas, S.; Bessiere, J.-M.,
Chemotaxonomic interest of volatile components in Lepista inversa and Lepista flaccida distinctions,
Cryptogamie, Mycologie, 2005, 26, 1, 1-4. [all data]
Stowell and Wilson, 1985
Stowell, A.; Wilson, L.,
Use of retention indices in drug screening by capillary gas chromatography, Rep. # CD 2362, Department of Scientific and Industrial Reseach, Chemistry Division, Lower Hutt, NZ, 1985, 32. [all data]
Ardrey and Moffat, 1981
Ardrey, R.E.; Moffat, A.C.,
Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase,
J. Chromatogr., 1981, 220, 3, 195-252, https://doi.org/10.1016/S0021-9673(00)81925-1
. [all data]
Notes
Go To: Top, IR Spectrum, THz IR spectrum, Gas Chromatography, References
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