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Indomethacin

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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled as indicated in comments:
TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Kenneth Kroenlein director
AC - William E. Acree, Jr., James S. Chickos

Quantity Value Units Method Reference Comment
Tfus433.KN/AGrady, Hays, et al., 1973Uncertainty assigned by TRC = 1. K; TRC

Enthalpy of fusion

DeltafusH (kJ/mol) Temperature (K) Method Reference Comment
43.5434.5DSCAceves-Hernandez, Nicolás-Vázquez, et al., 2009AC
36.5435.2DSCMurdande, Pikal, et al., 2009AC
39.99434.DSCBasavoju, Boström, et al., 2008AC
37.9433.DSCWassvik, Holmén, et al., 2006AC
37.8433.N/ALegendre and Feutelais, 2004See also Bergström, Wassvik, et al., 2007.; AC
36.49435.2N/AHancock and Parks, 2000AC

In addition to the Thermodynamics Research Center (TRC) data available from this site, much more physical and chemical property data is available from the following TRC products:


References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Grady, Hays, et al., 1973
Grady, L.T.; Hays, S.E.; King, R.H.; Klein, H.R.; Mader, W.J.; Wyatt, D.K.; Zimmere, R.O., Drug purity profiles, J. Pharm. Sci., 1973, 62, 459. [all data]

Aceves-Hernandez, Nicolás-Vázquez, et al., 2009
Aceves-Hernandez, J.M.; Nicolás-Vázquez, I.; Aceves, F.J.; Hinojosa-Torres, J.; Paz, M.; Castaño, V.M., Indomethacin polymorphs: Experimental and conformational analysis, J. Pharm. Sci., 2009, 98, 7, 2448-2463, https://doi.org/10.1002/jps.21626 . [all data]

Murdande, Pikal, et al., 2009
Murdande, Sharad B.; Pikal, Michael J.; Shanker, Ravi M.; Bogner, Robin H., Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis, J. Pharm. Sci., 2009, 99, 3, 1254-1264, https://doi.org/10.1002/jps.21903 . [all data]

Basavoju, Boström, et al., 2008
Basavoju, Srinivas; Boström, Dan; Velaga, Sitaram P., Indomethacin--Saccharin Cocrystal: Design, Synthesis and Preliminary Pharmaceutical Characterization, Pharm Res, 2008, 25, 3, 530-541, https://doi.org/10.1007/s11095-007-9394-1 . [all data]

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Legendre and Feutelais, 2004
Legendre, B.; Feutelais, Y., Polymorphic and Thermodynamic Study of Indomethacin, Journal of Thermal Analysis and Calorimetry, 2004, 76, 1, 255-264, https://doi.org/10.1023/B:JTAN.0000027824.55280.37 . [all data]

Bergström, Wassvik, et al., 2007
Bergström, Christel A.S.; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina, Poorly Soluble Marketed Drugs Display Solvation Limited Solubility, J. Med. Chem., 2007, 50, 23, 5858-5862, https://doi.org/10.1021/jm0706416 . [all data]

Hancock and Parks, 2000
Hancock, Bruno C.; Parks, Michael, Organometallics, 2000, 17, 4, 397-404, https://doi.org/10.1023/A:1007516718048 . [all data]


Notes

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