Oxazepam
- Formula: C15H11ClN2O2
- Molecular weight: 286.713
- IUPAC Standard InChI: InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)
- IUPAC Standard InChIKey: ADIMAYPTOBDMTL-UHFFFAOYSA-N
- CAS Registry Number: 604-75-1
- Chemical structure:
This structure is also available as a 2d Mol file - Other names: 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-; Adumbran; Aplakil; Astress; Bonare; Drimuel; Droxacepam; Enidrel; Hi-Long; Limbial; Nesontil; Praxiten; Propax; Psiquiwas; Ro 5-6789; Rondar; Serax; Serenal; Serepax; Seresta; Sobril; Tazepam; Wy-3498; Ansioxacepam; Anxiolit; CB 8092; Isodin; Murelax; Pacienx; Psicopax; Quilibrex; QUEN; Sedigoa; Serenid; Serenid-D; Serpax; Tacepam; Tranquo-buscopan-wirkstoff; Vaben; Z10-TR; 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepine-2-one; 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Azutranquil; Durazepam; Lederpam; Noctazepam; Oxa-puren; Oxanid; Sigacalm; Uskan; Zaxopam; 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; (RS)-Oxazepam; Nozepam; Nortemazepam; (.+/-.)-Oxazepam; Tarchomin; Ansiolisina; Notaral; Oxozepam; Wy-3498 stic; Camazepam-metabolite; Clorazepate-metabolite; Diazepam-metabolite; Ketazolam-metabolite; Temazepam-metabolite; Serepax;; Halazepam M (oxazepam), artifact; Ketazolam M (oxazepam), artifact 2; Ketazolam M (oxazepam), artifact 1; 7-Chloro-1,3-dihydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one ((±)-oxazepam)
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Normal alkane RI, non-polar column, custom temperature program
Go To: Top, References, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director
| Column type | Capillary | Capillary | Capillary | Capillary | Capillary |
|---|---|---|---|---|---|
| Active phase | Polydimethyl siloxanes | CP Sil 5 CB | CP Sil 5 CB | SPB-1 | BP-1 |
| Column length (m) | 10. | 10. | 25. | 12. | |
| Carrier gas | He | He | |||
| Substrate | Chromosorb W(100-120 mesh) | ||||
| Column diameter (mm) | 0.53 | 0.53 | 0.22 | ||
| Phase thickness (μm) | 5.2 | 5.2 | 0.4 | 0.25 | |
| Program | not specified | 100 0C (2 min) 20 0C/min -> 180 0C 7.5 0C/min -> 280 0C (6 min) | not specified | 120 0X 8 0C/min -> 270 0C 25 0C/min -> 300 0C (5 min) | |
| I | 2336. | 2310. | 2336. | 2314. | 2300. |
| Reference | Schutz and Wollrab A., 1988 | Bogusz, Bialka, et al., 1986 | Bogusz, Bialka, et al., 1986 | Chiarotti, de Giovanni, et al., 1986 | Stowell and Wilson, 1985 |
| Comment | MSDC-RI | MSDC-RI | MSDC-RI | MSDC-RI | MSDC-RI |
| Column type | Capillary | Other |
|---|---|---|
| Active phase | BP-1 | Methyl Silicone |
| Column length (m) | 12. | |
| Carrier gas | He | |
| Substrate | ||
| Column diameter (mm) | 0.22 | |
| Phase thickness (μm) | 0.25 | |
| Program | not specified | not specified |
| I | 2335. | 2336. |
| Reference | Stowell and Wilson, 1985 | Ardrey and Moffat, 1981 |
| Comment | MSDC-RI | MSDC-RI |
References
Go To: Top, Normal alkane RI, non-polar column, custom temperature program, Notes
Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.
Schutz and Wollrab A., 1988
Schutz, H.; Wollrab A.,
The significance of the retention index in toxicologic analysis II,
Pharmazie in unzerer Zeit, 1988, 17, 4, 97-101. [all data]
Bogusz, Bialka, et al., 1986
Bogusz, M.; Bialka, J.; Gierz, J.; Klys, M.,
Use of short, wide-bore capillary columns in GC toxicological screening,
J. Anal. Toxicol., 1986, 10, 4, 135-138, https://doi.org/10.1093/jat/10.4.135
. [all data]
Chiarotti, de Giovanni, et al., 1986
Chiarotti, M.; de Giovanni, N.; Fiori, A.,
Analysis of Benzodiazepines. I. Chromatographic Identification,
J. Chromatogr., 1986, 358, 169-178, https://doi.org/10.1016/S0021-9673(01)90326-7
. [all data]
Stowell and Wilson, 1985
Stowell, A.; Wilson, L.,
Use of retention indices in drug screening by capillary gas chromatography, Rep. # CD 2362, Department of Scientific and Industrial Reseach, Chemistry Division, Lower Hutt, NZ, 1985, 32. [all data]
Ardrey and Moffat, 1981
Ardrey, R.E.; Moffat, A.C.,
Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phase,
J. Chromatogr., 1981, 220, 3, 195-252, https://doi.org/10.1016/S0021-9673(00)81925-1
. [all data]
Notes
Go To: Top, Normal alkane RI, non-polar column, custom temperature program, References
- Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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