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Naproxen

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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of sublimation

DeltasubH (kJ/mol) Temperature (K) Method Reference
128.3 ± 0.5341. - 397.GSPerlovich, Kurkov, et al., 2004

Enthalpy of fusion

DeltafusH (kJ/mol) Temperature (K) Method Reference
34.2428.8DSCWassvik, Holmén, et al., 2006
31.5428.5N/ANeau, Bhandarkar, et al., 1997
29.41439.2N/AClaramonte, Vialard, et al., 1993

Mass spectrum (electron ionization)

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Mass spectrum
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Additional Data

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Owner NIST Mass Spectrometry Data Center
Collection (C) 2014 copyright by the U.S. Secretary of Commerce
on behalf of the United States of America. All rights reserved.
Origin Japan AIST/NIMC Database- Spectrum MS-IW-3664
NIST MS number 237147

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Gas Chromatography

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Normal alkane RI, non-polar column, temperature ramp

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Column type Active phase I Reference Comment
CapillaryDB-12032.Anderson and Fuller, 198710. m/0.53 mm/2.65 «mu»m, He, 5. K/min; Tstart: 130. C; Tend: 230. C
CapillaryDB-12053.Sharp, 198715. m/0.25 mm/0.25 «mu»m, He, 130. C @ 1. min, 10. K/min, 290. C @ 10. min

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Perlovich, Kurkov, et al., 2004
Perlovich, German L.; Kurkov, Sergey V.; Kinchin, Andrey N.; Bauer-Brandl, Annette, Thermodynamics of solutions III: comparison of the solvation of (+)-naproxen with other NSAIDs, European Journal of Pharmaceutics and Biopharmaceutics, 2004, 57, 2, 411-420, https://doi.org/10.1016/j.ejpb.2003.10.021 . [all data]

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Neau, Bhandarkar, et al., 1997
Neau, Steven H.; Bhandarkar, Satej V.; Hellmuth, Eckhard W., Pharmaceutical Research, 1997, 14, 5, 601-605, https://doi.org/10.1023/A:1012148910975 . [all data]

Claramonte, Vialard, et al., 1993
Claramonte, M.D. Contreras; Vialard, A. Parera; Vilchez, F. Girela, An application of regular solution theory in the study of the solubility of naproxen in some solvents used in topical preparations, International Journal of Pharmaceutics, 1993, 94, 1-3, 23-30, https://doi.org/10.1016/0378-5173(93)90005-Z . [all data]

Anderson and Fuller, 1987
Anderson, W.H.; Fuller, D.C., A simplified procedure for the isolation, characterization, and identification of weak acid and neutral drugs from whole blood, J. Anal. Toxicol., 1987, 11, 5, 198-204, https://doi.org/10.1093/jat/11.5.198 . [all data]

Sharp, 1987
Sharp, M.E., A rapid screening procedure for acidic and neutral drugs in blood by high resolution gas chromatography, J. Anal. Toxicol., 1987, 11, 1, 8-11, https://doi.org/10.1093/jat/11.1.8 . [all data]


Notes

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