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Ketoprofen


Phase change data

Go To: Top, Mass spectrum (electron ionization), Gas Chromatography, References, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of sublimation

DeltasubH (kJ/mol) Temperature (K) Method Reference
110.1 ± 0.5341. - 365.GSPerlovich, Kurkov, et al., 2003

Enthalpy of fusion

DeltafusH (kJ/mol) Temperature (K) Method Reference Comment
37.3368.DSCWassvik, Holmén, et al., 2006See also Wassvik, Holmén, et al., 2008.
25.04369.N/AMura, 1998See also Mura, Faucci, et al., 1999.
28.23367.4N/AEspitalier, Biscans, et al., 1995 

Mass spectrum (electron ionization)

Go To: Top, Phase change data, Gas Chromatography, References, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Spectrum

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Additional Data

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Owner NIST Mass Spectrometry Data Center
Collection (C) 2014 copyright by the U.S. Secretary of Commerce
on behalf of the United States of America. All rights reserved.
Origin Patti Price, Georgia Bureau of Investigation, Decatur, Georgia
NIST MS number 248419

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Gas Chromatography

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: NIST Mass Spectrometry Data Center, William E. Wallace, director

Normal alkane RI, non-polar column, temperature ramp

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Column type Active phase I Reference Comment
CapillaryDB-12185.Sharp, 198715. m/0.25 mm/0.25 «mu»m, He, 130. C @ 1. min, 10. K/min, 290. C @ 10. min

References

Go To: Top, Phase change data, Mass spectrum (electron ionization), Gas Chromatography, Notes

Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Perlovich, Kurkov, et al., 2003
Perlovich, German L.; Kurkov, Sergey V.; Kinchin, Andrey N.; Bauer-Brandl, Annette, Thermodynamics of solutions IV: Solvation of ketoprofen in comparison with other NSAIDs, J. Pharm. Sci., 2003, 92, 12, 2502-2511, https://doi.org/10.1002/jps.10512 . [all data]

Wassvik, Holmén, et al., 2006
Wassvik, Carola M.; Holmén, Anders G.; Bergström, Christel A.S.; Zamora, Ismael; Artursson, Per, Contribution of solid-state properties to the aqueous solubility of drugs, European Journal of Pharmaceutical Sciences, 2006, 29, 3-4, 294-305, https://doi.org/10.1016/j.ejps.2006.05.013 . [all data]

Wassvik, Holmén, et al., 2008
Wassvik, Carola M.; Holmén, Anders G.; Draheim, Rieke; Artursson, Per; Bergström, Christel A.S., Molecular Characteristics for Solid-State Limited Solubility, J. Med. Chem., 2008, 51, 10, 3035-3039, https://doi.org/10.1021/jm701587d . [all data]

Mura, 1998
Mura, P., Interactions of ketoprofen and ibuprofen with «beta»-cyclodextrins in solution and in the solid state, International Journal of Pharmaceutics, 1998, 166, 2, 189-203, https://doi.org/10.1016/S0378-5173(98)00035-0 . [all data]

Mura, Faucci, et al., 1999
Mura, P.; Faucci, M.T.; Parrini, P.L.; Furlanetto, S.; Pinzauti, S., Influence of the preparation method on the physicochemical properties of ketoprofen--cyclodextrin binary systems, International Journal of Pharmaceutics, 1999, 179, 1, 117-128, https://doi.org/10.1016/S0378-5173(98)00390-1 . [all data]

Espitalier, Biscans, et al., 1995
Espitalier, F.; Biscans, B.; Peyrigain, P. Sere; Laguérie, C., Ternary diagram: alpha-(3-benzoylphenyl)-propionic acid (ketoprofen) in acetone«58872»water mixtures at different temperatures. Experimental data and predicted results, Fluid Phase Equilibria, 1995, 113, 1-2, 151-171, https://doi.org/10.1016/0378-3812(95)02806-8 . [all data]

Sharp, 1987
Sharp, M.E., A rapid screening procedure for acidic and neutral drugs in blood by high resolution gas chromatography, J. Anal. Toxicol., 1987, 11, 1, 8-11, https://doi.org/10.1093/jat/11.1.8 . [all data]


Notes

Go To: Top, Phase change data, Mass spectrum (electron ionization), Gas Chromatography, References