Felodipine

• Formula: C₁₈H₁₉Cl₂NO₄
• Molecular weight: 384.254
• IUPAC Standard InChI: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3 Copy

  
• IUPAC Standard InChIKey: RZTAMFZIAATZDJ-UHFFFAOYSA-N Copy
• CAS Registry Number: 72509-76-3
• Chemical structure:
  This structure is also available as a 2d Mol file or as a computed 3d SD file
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• Other names: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester; Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; (.+/-.) Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester; Agon; Feloday; Felodipine (dl form); Flodil; H-154/82; Hydac; Munobal; Plendil; Prevex; Splendil; (.+/-.)-Felodipine; dl-Felodipine; Plandil; 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate; (±) Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(2,3-dichlorophenyl)-3,5-pyridine dicarboxylate (felodipine)
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• Information on this page:
  • Phase change data
  • References
  • Notes
• Other data available:
  • Mass spectrum (electron ionization)
  • Gas Chromatography
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Phase change data

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Data compiled by: William E. Acree, Jr., James S. Chickos

Enthalpy of fusion

References

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Data compilation copyright by the U.S. Secretary of Commerce on behalf of the U.S.A. All rights reserved.

Bergström, Wassvik, et al., 2007
Bergström, Christel A.S.; Wassvik, Carola M.; Johansson, Kajsa; Hubatsch, Ina, Poorly Soluble Marketed Drugs Display Solvation Limited Solubility, J. Med. Chem., 2007, 50, 23, 5858-5862, https://doi.org/10.1021/jm0706416 . [all data]

Srcic, Kerc, et al., 1992
Srcic, S.; Kerc, J.; Urleb, U.; Zupancic, I.; Lahajnar, G.; Kofler, B.; Smid-Korbar, J., Investigation of felodipine polymorphism and its glassy state, International Journal of Pharmaceutics, 1992, 87, 1-3, 1-10, https://doi.org/10.1016/0378-5173(92)90221-M . [all data]

Notes

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• Symbols used in this document:
  

  ΔfusH

  Enthalpy of fusion

• Data from NIST Standard Reference Database 69: NIST Chemistry WebBook
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